Incidence and Factors Associated with HIV Virologic Failure among Adults Undergoing First-Line Antiretroviral Therapy : a Five-Year Retrospective Study in Thailand
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CiNii Research
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- 資料種別
- 記事
- 著者・編者
- Lantharita CharoenpongChalor SantiwarangkanaWeerawat Manosuthi
- タイトル（掲載誌）
- Japanese Journal of Infectious Diseases
- 巻号年月日等（掲載誌）
- 78(6):2025.11
- 掲載巻
- 78
- 掲載号
- 6
- 掲載ページ
- 204-210
- 掲載年月日（W3CDTF）
- 2025-11
- ISSN（掲載誌）
- 1344-6304
- ISSN-L（掲載誌）
- 1344-6304
- 出版事項（掲載誌）
- Tokyo : National Institute of Infectious Diseases
- 出版地（国名コード）
- JP
- 本文の言語コード
- eng
- NDLC
- 対象利用者
- 一般
- 所蔵機関
- 国立国会図書館
- 請求記号
- Z53-C450
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- 書誌ID（NDLBibID）
- 034456089
- 整理区分コード
- 632
- 要約等
- <p>Virologic failure and HIV drug resistance have emerged with the widespread use of antiretroviral therapy (ART). An understanding of these predictors is the basis for prevention strategies to achieve a high treatment success rate. A retrospective cohort study was conducted among antiretroviral-naïve people living with HIV (PLWH) registered in the national AIDS program database of the National Health Security Office Region 4, Thailand, between January 2014 and December 2018. To determine the cumulative incidence rate of virologic failure and related factors, all PLWH were monitored for viral load status through December 2019. Virologic failure was defined as HIV viral load >1,000 copies/mL after 6 months of ART. Of the 42,229 PLWH identified, 10,211 PLWH with primary ART regimens and follow-up data were included. There were 67.1% males, and the mean age was 35 years (standard deviation: 11.6 years). During the median observation period of 0.88 years (interquartile range: 0.23–1.94 years) after ART initiation, 2.4% (242/10,211) of the PLWH experienced virologic failure. The Cox proportional hazard model revealed that the risk of developing virologic failure was significantly associated with age <30 years and baseline CD4 cell count ≤200 cells/mm<sup>3</sup> . Active case finding, early ART initiation, and strengthening of the HIV continuum of care intervention are strongly recommended in order to minimize treatment failure.</p>
- DOI
- 10.7883/yoken.jjid.2023.409
- 関連情報（URI）
- 参照
- First-Line Antiretroviral Regimen Failure and Determinants in an Urban HIV Clinic at Phramongkutklao Hospital, Bangkok, Thailand: 20 Years ExperienceHIV Drug Resistance in Adults Receiving Early vs. Delayed Antiretroviral Therapy: HPTN 052HIV Drug Resistance among Pre-treatment Cases in Thailand: Four Rounds of Surveys during 2006-2013HIV Treatment Adherence, Drug Resistance, Virologic Failure: Evolving ConceptsBrief Report: HIV Drug Resistance in Adults Failing Early Antiretroviral Treatment: Results From the HIV Prevention Trials Network 052 TrialVirological and immunological failure of HAART and associated risk factors among adults and adolescents in the Tigray region of Northern EthiopiaAssociations between baseline characteristics, CD4 cell count response and virological failure on first-line efavirenz + tenofovir + emtricitabine for HIVHealth Care Transition for Youth Living With HIV/AIDSGuidelines for antiretroviral therapy in HIV-1 infected adults and adolescents 2014, ThailandEpidemiologic and viral predictors of antiretroviral drug resistance among persons living with HIV in a large treatment program in NigeriaA clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infectionHIV-1 drug-resistant mutations and related risk factors among HIV-1-positive individuals experiencing treatment failure in Hebei Province, ChinaOutcome of Sentinel Hospital-based and CDC-based ART Service Delivery: A Prospective Open Cohort of People Living with HIV in ChinaPrevalence of HIV Antiretroviral Drug Resistance and Its Impacts on HIV-1 Virological Failures in Jiangsu, China: A Cross-Sectional StudyInterventions to Improve Antiretroviral Therapy Adherence Among Adolescents and Youth in Low- and Middle-Income Countries: A Systematic Review 2015–2019Patterns of acquired HIV-1 drug resistance mutations and predictors of virological failure in Moshi, Northern TanzaniaPredictors of virological treatment failure among adult HIV patients on first-line antiretroviral therapy in Woldia and Dessie hospitals, Northeast Ethiopia: a case-control studyOvercoming challenges across the HIV care continuum in the Asia-Pacific region: expert recommendationsHIV-1 drug resistance in Thailand: Before and after National Access to Antiretroviral ProgramIncidence and risk factors of antiretroviral treatment failure in treatment-naïve HIV-infected patients at Chiang Mai University Hospital, ThailandCorrigendum to “Trend of HIV-1 drug resistance in China: A systematic review and meta-analysis of data accumulated over 17 years (2001-2017)” [EClinicalMedicine 18 (2020) 100238]Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus InfectionTenofovir DF, Emtricitabine, and Efavirenz vs. Zidovudine, Lamivudine, and Efavirenz for HIVIncidence and Associated Factors of HIV Drug Resistance in Chinese HIV-Infected Patients Receiving Antiretroviral TreatmentOutcomes for Efavirenz versus Nevirapine-Containing Regimens for Treatment of HIV-1 Infection: A Systematic Review and Meta-Analysis
- 連携機関・データベース
- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Japan Link Center雑誌記事索引データベースCrossrefPubMed
- 書誌ID（NDLBibID）
- 034456089