Thielavin A and B,New Inhibitors of Prostaglandin Biosynthesis Produced by Thielavia terricola

• 資料種別: 記事
• タイトル: Thielavin A and B,New Inhibitors of Prostaglandin Biosynthesis Produced by Thielavia terricola
• 著者・編者: Nobuaki Kitahara 他
• 著者標目: Nobuaki Kitahara
• タイトル（掲載誌）: The journal of antibiotics : an international journal
• 巻号年月日等（掲載誌）: 34(12) 1981.12
• 掲載巻: 34
• 掲載号: 12
• 掲載ページ: p1562～1568
• 掲載年月日（W3CDTF）: 1981-12
• ISSN（掲載誌）: 0021-8820
• ISSN-L（掲載誌）: 0021-8820
• 出版事項（掲載誌）: Tokyo : Japan Antibiotics Research Association
• 出版地（国名コード）: JP
• 本文の言語コード: eng
• NDLC: ZS51
• 対象利用者: 一般
• 記事種別、記事分類: 記事分類: 薬学
• 所蔵機関: 国立国会図書館
• 請求記号: Z53-D224
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 2477331; http://id.ndl.go.jp/bib/2477331
• 整理区分コード: 632

• 要約等: Two potent inhibitors of prostaglandin biosynthesis, thielavin A (C₃₁H₃₄O₁₀) and B(C₂₉H₃₀O₁₀), were isolated from cultures of <i>Thielavia terricola</i>. Both of these compounds were shown to be structurally related to depsides, thus consisting of three hydroxybenzoic acid groups. Concentrations required for 50% inhibition of the conversion of ¹⁴C-arachidonic acid into prostaglandins F_2α, plus E₂ by microsomes of ram seminal vesicles were 12 μM for thielavin A and 9 μM for thielavin B, respectively. Of the enzymatic steps involved in prostaglandin synthesis, thielavin A specifically inhibited the conversion of arachidonic acid into prostaglandin H₂, while prostaglandin E₂ synthesis from the endoperoxide was the most sensitive to thielavin B.
• DOI: 10.7164/antibiotics.34.1562
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: Two potent inhibitors of prostaglandin biosynthesis, thielavin A (C₃₁H₃₄O₁₀) and B(C₂₉H₃₀O₁₀), were isolated from cultures of <i>Thielavia terricola</i>. Both of these compounds were shown to be structurally related to depsides, thus consisting of three hydroxybenzoic acid groups. Concentrations required for 50% inhibition of the conversion of ¹⁴C-arachidonic acid into prostaglandins F_2α, plus E₂ by microsomes of ram seminal vesicles were 12 μM for thielavin A and 9 μM for thielavin B, respectively. Of the enzymatic steps involved in prostaglandin synthesis, thielavin A specifically inhibited the conversion of arachidonic acid into prostaglandin H₂, while prostaglandin E₂ synthesis from the endoperoxide was the most sensitive to thielavin B.
• DOI: 10.7164/antibiotics.34.1562; https://doi.org/10.7164/antibiotics.34.1562
• 関連情報（URI）: http://id.ndl.go.jp/bib/2477331; https://ndlsearch.ndl.go.jp/books/R000000004-I2477331
• 参照: Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B.; https://cir.nii.ac.jp/crid/1390001206473784704
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles
• 書誌ID（NDLBibID）: 2477331; http://id.ndl.go.jp/bib/2477331
• NII論文ID: 130003499983; 40005315033