ツベルクリンアレルギーに関する研究-1-ツベルクリン反応発現に関与する感作細胞の機能と皮内反応部位の浸潤細胞との相関関係について

• 資料種別: 記事
• タイトル: ツベルクリンアレルギーに関する研究-1-ツベルクリン反応発現に関与する感作細胞の機能と皮内反応部位の浸潤細胞との相関関係について
• 著者・編者: 大山口 渥
• 著者標目: 大山口 渥
• タイトル（掲載誌）: 結核
• 巻号年月日等（掲載誌）: 57(2) 1982.02
• 掲載巻: 57
• 掲載号: 2
• 掲載ページ: p59～71
• 掲載年月日（W3CDTF）: 1982-02
• ISSN（掲載誌）: 0022-9776
• ISSN-L（掲載誌）: 0022-9776
• 出版事項（掲載誌）: 東京 : 日本結核・非結核性抗酸菌症学会
• 出版地（国名コード）: JP
• 本文の言語コード: jpn
• NDLC: ZS21
• 対象利用者: 一般
• 記事種別、記事分類: 記事分類: 医学--免疫学・血清学・アレルギー ; 医学--全身性伝染病
• 所蔵機関: 国立国会図書館
• 請求記号: Z19-133
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 2482425; http://id.ndl.go.jp/bib/2482425
• 整理区分コード: 632

• 要約等: There are two types of cell populations which mediate the tuberculin hypersensitivity: sensi-tized T lymphocytes and non-specific accessory cells. The present study was undertaken to eluci-date the identity of cells which can transfer tuberculin hypersensitivity, those which produce the macrophage migration inhibitory factor (MIF), and those which produce the leucocyte migration inhibitory factor (LIF). In addition, it was studied that the relation between the MIF or LIF producibilities of transferred sensitized cells and the composition of infiltrating cells in the skin reaction site in normal (non-irradiated) or irradiated (800 rad) recipients.<BR>The results were as follows:<BR>1. The ability of tuberculin-type hypersensitivity (TTH) transfer, MIF production and LIF production were equally prominent in the regional lymph node cells of guinea pigs vaccinated (V group) with heat-killed BCG.<BR>2. The ability of TTH transfer and LIF production were prominent, but MIF production was not detected in the spleen cells of the V group.<BR>3. The ability of TTH transfer and MIF production was detected in the regional lymph node cells of guinea pigs vaccinated and challenged (VC group) with heat-killed BCG, but that ability was weaker than that of regional lymph node cells of the V group. Leucocyte migration stimula-ting activity was observed in the regional lymph node cells of the VC group, but LIF production was not seen there.<BR>4. The ability of TTH transfer was most dominant in the spleen cells of the VC group. MIF production was also detected in the spleen cells, and was equal to that of the regional lymph node cells of the VC group. Leucocyte migration stimulating activity, but not LIF production, was observed in the spleen cells of the VC group, as was the case in the regional lymph node cells of the VC group.<BR>5. In the skin lesions of the PPD test on, normal or <SUP>60</SUP>Co-irradiated (800 rad) recipients, the number of infiltrating non-specific accessory cells, i. e., mononuclear cells or polymorphonuclear leucocytes, was not histopathologically parallel with the MIF or LIF producibilities of transferred sensitized regional lymph node cells or spleen cells of the V group.<BR>6. The PPD-skin lesions of <SUP>60</SUP>Co-irradiated (800 rad) recipients were macroscopically more prominent than those of normal (non-irradiated) recipients transferred with sensitized regional lymph node cells or with spleen cells of the V group. However, the total number of infiltrating cells in the skin lesions of irradiated recipients decreased to about half of the number in those of normal (non-irradiated) recipients.<BR>It was concluded that the ability of TTH transfer <I>in vivo</I> and the ability of MIF production <I>in vitro</I> are not always parallel, and that the ability of TTH transfer <I>in vivo</I> is parallel with the ability of each of LIF or leucocyte migration stimulating factor production <I>in vitro</I>, and that the total number of infiltrating cells in skin reaction site was not always correlated with the size of the skin reaction, but the number of infiltrating cells in the skin reaction site was strongly con-trolled by the total number of mobile cells in each animals.
• DOI: 10.11400/kekkaku1923.57.59
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: There are two types of cell populations which mediate the tuberculin hypersensitivity: sensi-tized T lymphocytes and non-specific accessory cells. The present study was undertaken to eluci-date the identity of cells which can transfer tuberculin hypersensitivity, those which produce the macrophage migration inhibitory factor (MIF), and those which produce the leucocyte migration inhibitory factor (LIF). In addition, it was studied that the relation between the MIF or LIF producibilities of transferred sensitized cells and the composition of infiltrating cells in the skin reaction site in normal (non-irradiated) or irradiated (800 rad) recipients.<BR>The results were as follows:<BR>1. The ability of tuberculin-type hypersensitivity (TTH) transfer, MIF production and LIF production were equally prominent in the regional lymph node cells of guinea pigs vaccinated (V group) with heat-killed BCG.<BR>2. The ability of TTH transfer and LIF production were prominent, but MIF production was not detected in the spleen cells of the V group.<BR>3. The ability of TTH transfer and MIF production was detected in the regional lymph node cells of guinea pigs vaccinated and challenged (VC group) with heat-killed BCG, but that ability was weaker than that of regional lymph node cells of the V group. Leucocyte migration stimula-ting activity was observed in the regional lymph node cells of the VC group, but LIF production was not seen there.<BR>4. The ability of TTH transfer was most dominant in the spleen cells of the VC group. MIF production was also detected in the spleen cells, and was equal to that of the regional lymph node cells of the VC group. Leucocyte migration stimulating activity, but not LIF production, was observed in the spleen cells of the VC group, as was the case in the regional lymph node cells of the VC group.<BR>5. In the skin lesions of the PPD test on, normal or <SUP>60</SUP>Co-irradiated (800 rad) recipients, the number of infiltrating non-specific accessory cells, i. e., mononuclear cells or polymorphonuclear leucocytes, was not histopathologically parallel with the MIF or LIF producibilities of transferred sensitized regional lymph node cells or spleen cells of the V group.<BR>6. The PPD-skin lesions of <SUP>60</SUP>Co-irradiated (800 rad) recipients were macroscopically more prominent than those of normal (non-irradiated) recipients transferred with sensitized regional lymph node cells or with spleen cells of the V group. However, the total number of infiltrating cells in the skin lesions of irradiated recipients decreased to about half of the number in those of normal (non-irradiated) recipients.<BR>It was concluded that the ability of TTH transfer <I>in vivo</I> and the ability of MIF production <I>in vitro</I> are not always parallel, and that the ability of TTH transfer <I>in vivo</I> is parallel with the ability of each of LIF or leucocyte migration stimulating factor production <I>in vitro</I>, and that the total number of infiltrating cells in skin reaction site was not always correlated with the size of the skin reaction, but the number of infiltrating cells in the skin reaction site was strongly con-trolled by the total number of mobile cells in each animals.
• DOI: 10.11400/kekkaku1923.57.59; https://doi.org/10.11400/kekkaku1923.57.59
• 関連情報（URI）: http://id.ndl.go.jp/bib/2482425; https://ndlsearch.ndl.go.jp/books/R000000004-I2482425; https://search.jamas.or.jp/link/ui/1982171625
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles
• 書誌ID（NDLBibID）: 2482425; http://id.ndl.go.jp/bib/2482425
• NII論文ID: 130001416740