Effects of Mitomycin C Treatment before Implantation on Development of Mouse Embryo

• 資料種別: 記事
• タイトル: Effects of Mitomycin C Treatment before Implantation on Development of Mouse Embryo
• 著者・編者: 長尾 哲二; 石塚 康夫; 水谷 正寛
• 著者標目: 長尾 哲二; 石塚 康夫; 水谷 正寛
• タイトル（掲載誌）: 先天異常 = Congenital anomalies
• 巻号年月日等（掲載誌）: 26(2) 1986.06
• 掲載巻: 26
• 掲載号: 2
• 掲載ページ: p93～101
• 掲載年月日（W3CDTF）: 1986-06
• ISSN（掲載誌）: 0037-2285
• ISSN-L（掲載誌）: 0037-2285
• 出版事項（掲載誌）: 狭山町 (大阪府) : 日本先天異常学会
• 出版地（国名コード）: JP
• 本文の言語コード: jpn
• NDLC: ZS32
• 対象利用者: 一般
• 記事種別、記事分類: 記事分類: 医学--先天異常・奇形
• 所蔵機関: 国立国会図書館
• 請求記号: Z19-333
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 3098705; http://id.ndl.go.jp/bib/3098705
• 整理区分コード: 632

• 要約等: ABSTRACT ICR mice were treated intraperitoneally with mitomycin C (MMC) at a single dose of l-5mg/kg on day 0, 1, 2 or 3 of pregnancy (vaginal plug = day 0). Embryotoxicity and teratogenicity were examined at term. A dose-dependent increase in fetal mortality and decrease in the number of im- plants, fetal weight or number of ossified sacral and caudal vertebrae were observed. The incidence of external malformation, umbilical hernia, significantly increased among the fetuses of dams treated with MMC at Smg/kg on day 1, 2 or 3. Skeletal malformation failed to show significant increase though some fetuses from MMC- treated mice were attended with multiple defects such as fusion of ribs or axial skeleton. Maternal contribution to and the direct action of MMC on embryonic develop- ment were investigated by embryo transfer. In regard to malformation inducement and decrease in implants, the maternal environment was found to have more signifi- cant effect than the direct action of this drug but both these factors are significant- ly responsible for increased fetal mortality and growth retardation.
• DOI: 10.24540/cgafa.26.2_93
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: ABSTRACT ICR mice were treated intraperitoneally with mitomycin C (MMC) at a single dose of l-5mg/kg on day 0, 1, 2 or 3 of pregnancy (vaginal plug = day 0). Embryotoxicity and teratogenicity were examined at term. A dose-dependent increase in fetal mortality and decrease in the number of im- plants, fetal weight or number of ossified sacral and caudal vertebrae were observed. The incidence of external malformation, umbilical hernia, significantly increased among the fetuses of dams treated with MMC at Smg/kg on day 1, 2 or 3. Skeletal malformation failed to show significant increase though some fetuses from MMC- treated mice were attended with multiple defects such as fusion of ribs or axial skeleton. Maternal contribution to and the direct action of MMC on embryonic develop- ment were investigated by embryo transfer. In regard to malformation inducement and decrease in implants, the maternal environment was found to have more signifi- cant effect than the direct action of this drug but both these factors are significant- ly responsible for increased fetal mortality and growth retardation.
• DOI: 10.24540/cgafa.26.2_93; https://doi.org/10.24540/cgafa.26.2_93; 10.1111/j.1741-4520.1986.tb00662.x; https://doi.org/10.1111/j.1741-4520.1986.tb00662.x
• 関連情報（URI）: http://id.ndl.go.jp/bib/3098705; https://ndlsearch.ndl.go.jp/books/R000000004-I3098705; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.1986.tb00662.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.1986.tb00662.x; https://search.jamas.or.jp/link/ui/1988185548
• 参照: Embryonic mortality and intrauterine growth retardation (IUGR) associated with placental alterations in pregnant rats treated with methyl methanesulfonate (MMS) at the peri-implantation stage; https://cir.nii.ac.jp/crid/1390001204900801152; DIFFERENTIAL SUSCEPTIBILITY OF RAT EMBRYOS TO METHYL METHANESULFONATE DURING THE PREGASTRULATION PERIOD; https://cir.nii.ac.jp/crid/1390282679878220544; Treatment of Mouse Preimplantation Embryos with Adriamycin, Methyl Methanesulfonate and Retinoic Acid Results in Congenital Defects; https://cir.nii.ac.jp/crid/1390288867187944320; Developmental Abnormalities Due to Exposure of Mouse Paternal Germ Cells, Preimplantation Embryos, and Organogenic Embryos to Acrylamide; https://cir.nii.ac.jp/crid/1390570331085565312; Exposure to Ethylnitrosourea Before Implantation Induces Congenital Malformations in Mouse Fetuses; https://cir.nii.ac.jp/crid/1390851817140545536
• 参照: Asynchronous Transfer of Mouse Ova; https://cir.nii.ac.jp/crid/1360011144359742336; THE DEVELOPMENT OF MOUSE BLASTOCYSTS INJECTED WITH, OR CULTURED IN, TRYPAN BLUE SOLUTION; https://cir.nii.ac.jp/crid/1360011144866144384; Elimination of spontaneous and chemically induced chromosome aberrations in mice during early embryogenesis; https://cir.nii.ac.jp/crid/1360011146024261120; Teratogenic effects of methylnitrosourea on pregnant mice before implantation; https://cir.nii.ac.jp/crid/1360574095421618944; Ausl�sung von Blastopathien beim S�ugetier durch Cyclophosphamid und Thalidomid; https://cir.nii.ac.jp/crid/1360579818190773120; A Note on the Staining of the Skeleton of Cleared Specimens with Alizarin Red S; https://cir.nii.ac.jp/crid/1362262945076775808; An analysis of the changing radiation response of the developing mouse embryo; https://cir.nii.ac.jp/crid/1362544420996760064; Mammalian Blastopathies due to Drugs; https://cir.nii.ac.jp/crid/1363951794674162944; Deleterious effects of environmental chemicals on developing cultured early mouse embryos; https://cir.nii.ac.jp/crid/1370579813166117248; Studies on the transfer of fertilized mouse eggs to uterine foster‐mothers: I; https://cir.nii.ac.jp/crid/1370579813166117250; X‐irradiation exence‐phaly; https://cir.nii.ac.jp/crid/1370579813166117251; Das Eutstehen bestimmter äuβerer Miβbildungen als Folge exogener Reize beim Säugetier; https://cir.nii.ac.jp/crid/1370579813166117254; Cultrure and Transfer of Embryos as a Testing System for Embryo‐toxicity of Chemicals*; https://cir.nii.ac.jp/crid/1390007216691846016; マウス胎仔の成長速度の系統差の由来 : 受精卵移植法による研究; https://cir.nii.ac.jp/crid/1390564238074742528; An analysis of the changing urethan response of the developing mouse embryo in relation to mortality, malformation and neoplasm; https://cir.nii.ac.jp/crid/1570572699702610304
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; CiNii Articles
• 書誌ID（NDLBibID）: 3098705; http://id.ndl.go.jp/bib/3098705
• NII論文ID: 110002728963