成人型アトピー性皮膚炎に対する草津温泉療法--100症例の治療経験

• 資料種別: 記事
• タイトル: 成人型アトピー性皮膚炎に対する草津温泉療法--100症例の治療経験
• 著者・編者: 久保田 一雄; 倉林 均; 田村 耕成 他
• 著者標目: 久保田 一雄; 倉林 均; 田村 耕成
• タイトル（掲載誌）: 日本温泉気候物理医学会雑誌 = The journal of balneology, climatology and physical medicine
• 巻号年月日等（掲載誌）: 62(2) 1999.02
• 掲載巻: 62
• 掲載号: 2
• 掲載ページ: 71～79
• 掲載年月日（W3CDTF）: 1999-02
• ISSN（掲載誌）: 0029-0343
• ISSN-L（掲載誌）: 0029-0343
• 出版事項（掲載誌）: 東京 : 日本温泉気候物理医学会
• 出版地（国名コード）: JP
• 本文の言語コード: jpn
• NDLC: ZS47
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z19-225
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 4653753; http://id.ndl.go.jp/bib/4653753
• 整理区分コード: 632

• 要約等: From June 1990 to October 1998, 100 patients with adult-type atopic dermatitis (59 males and 41 females, 25±8 years) were admitted to our hospital to receive balneotherapy using Kusatsu hot-spring water. The atopic dermatitis in all but 9 cases occurred while the patients were still under 20 and had been refractory to various treatments including steroid ointment therapy over a long period of time. The patients took a 10-minute 40-42°C hot-spring bath followed by immediate application of white petrolatum 1-2 times daily for 75±46 days. The main components of the hot-spring water are aluminium, sulphates and chlorides, and its pH is 2.0. The skin symptoms of 79 of 100 cases (79%) were improved through the balneotherapy and furthermore pruritus was improved in 55 of the 79 cases (70%). The improvement of skin manifestations was supported by a significant decrease in serum LDH levels. In contrast, pruritus was not improved in the remaining 21 cases who showed no changes in skin symptoms and serum LDH levels. Moreover, changes in the number of <i>Staphylococcus aureus</i> on the skin surface were examined before and after balneotherapy. In the 69 cases examined whose skin symptoms were improved, many <i>Staphylococci aureus</i> were detected in 52 of the cases but not in the other 17 cases before starting balneotherapy. They disappeared in 24 cases and decreased in 18 cases of the 52 cases, but were not changed in the remaining 10 cases through the balneotherapy. On the other hand, the number of <i>Staphylococcus aureus</i> on the skin surface was not changed in 11 of the 14 cases examined whose skin symptoms were not improved. Our previous study reported that bactericidal activity against <i>Staphylococcus aureus</i> is expressed by the co-existence of manganese and iodide ions contained in the hot-spring water under an acidic (pH 2.0-3.0) condition. Thus, the mechanisms of the improvement of skin manifestations through the balneotherapy may be explained by considering bactericidal activity of Kusatsu hot-spring water against <i>Staphylococcus aureus</i> inducing acute flares of skin manifestations. Therefore, balneotherapy at Kusatsu can be useful for the treatment of refractory cases of adult-type atopic dermatitis as a suitable method of skin care.
• DOI: 10.11390/onki1962.62.71
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: From June 1990 to October 1998, 100 patients with adult-type atopic dermatitis (59 males and 41 females, 25±8 years) were admitted to our hospital to receive balneotherapy using Kusatsu hot-spring water. The atopic dermatitis in all but 9 cases occurred while the patients were still under 20 and had been refractory to various treatments including steroid ointment therapy over a long period of time. The patients took a 10-minute 40-42°C hot-spring bath followed by immediate application of white petrolatum 1-2 times daily for 75±46 days. The main components of the hot-spring water are aluminium, sulphates and chlorides, and its pH is 2.0. The skin symptoms of 79 of 100 cases (79%) were improved through the balneotherapy and furthermore pruritus was improved in 55 of the 79 cases (70%). The improvement of skin manifestations was supported by a significant decrease in serum LDH levels. In contrast, pruritus was not improved in the remaining 21 cases who showed no changes in skin symptoms and serum LDH levels. Moreover, changes in the number of <i>Staphylococcus aureus</i> on the skin surface were examined before and after balneotherapy. In the 69 cases examined whose skin symptoms were improved, many <i>Staphylococci aureus</i> were detected in 52 of the cases but not in the other 17 cases before starting balneotherapy. They disappeared in 24 cases and decreased in 18 cases of the 52 cases, but were not changed in the remaining 10 cases through the balneotherapy. On the other hand, the number of <i>Staphylococcus aureus</i> on the skin surface was not changed in 11 of the 14 cases examined whose skin symptoms were not improved. Our previous study reported that bactericidal activity against <i>Staphylococcus aureus</i> is expressed by the co-existence of manganese and iodide ions contained in the hot-spring water under an acidic (pH 2.0-3.0) condition. Thus, the mechanisms of the improvement of skin manifestations through the balneotherapy may be explained by considering bactericidal activity of Kusatsu hot-spring water against <i>Staphylococcus aureus</i> inducing acute flares of skin manifestations. Therefore, balneotherapy at Kusatsu can be useful for the treatment of refractory cases of adult-type atopic dermatitis as a suitable method of skin care.
• DOI: 10.11390/onki1962.62.71; https://doi.org/10.11390/onki1962.62.71
• 関連情報（URI）: http://id.ndl.go.jp/bib/4653753; https://ndlsearch.ndl.go.jp/books/R000000004-I4653753; https://search.jamas.or.jp/link/ui/1999153655
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; CiNii Articles
• 書誌ID（NDLBibID）: 4653753; http://id.ndl.go.jp/bib/4653753
• NII論文ID: 10005968392; 10005968686