The Contribution of Acute Toxicity in Animals to Occupational Exposure Limits of Chemical Substances

• 資料種別: 記事
• タイトル: The Contribution of Acute Toxicity in Animals to Occupational Exposure Limits of Chemical Substances
• 著者・編者: Megumi Suda; Hiroshi Tsuruta; Takeshi Honma
• 著者標目: Megumi Suda; Hiroshi Tsuruta; Takeshi Honma
• タイトル（掲載誌）: Industrial health
• 巻号年月日等（掲載誌）: 37(1) 1999.01
• 掲載巻: 37
• 掲載号: 1
• 掲載ページ: 22～37
• 掲載年月日（W3CDTF）: 1999-01
• ISSN（掲載誌）: 0019-8366
• ISSN-L（掲載誌）: 0019-8366
• 出版事項（掲載誌）: Kawasaki : National Institute of Occupational Safety and Health
• 出版地（国名コード）: JP
• 本文の言語コード: eng
• NDLC: ZE12
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z51-F156
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 4682575; http://id.ndl.go.jp/bib/4682575
• 整理区分コード: 632

• 要約等: The correlations of lethal doses of various industrial chemicals for rats and mice with occupational exposure limit values were investigated. 50% lethal dose (LD₅₀) values obtained by oral (p.o.) and intraperitoneal (i.p.) injection and 50% lethal concentration (LC₅₀) values obtained by inhalation exposure were collected from Registry of Toxic Effects of Chemical Substances (RTECS). Threshold Limit Value (Time-Weighted Average) (TLVs-TWA) and Threshold Limit Value (Short Term Exposure Limit) (TLVs-STEL) recommended by American Conference of Governmental Industrial Hygienists (ACGIH) were used as exposure limits. TLVs-TWA or TLVs-STEL and LD₅₀ or LC₅₀ values obtained for the rats were plotted on logarithmic scales on the ordinate and abscissa, respectively. High correlations were obtained between these parameters. The order of correlations was: TLVs-STEL <i>vs</i>. LC₅₀s>TLVs-TWA <i>vs</i>. LC₅₀s>TLVs-TWA <i>vs</i>. LD₅₀s i.p.>TLVs <i>vs</i>. LD₅₀s p.o. The same calculations for the relationship between TLVs and lethal doses in mice were also performed. The order of the three types of correlations was same as that of the rats; however, correlation coefficients for TLVs-STEL <i>vs</i>. LC₅₀s and for TLVs-TWA <i>vs</i>. LC₅₀s obtained in mice were smaller than those in rats. TLVs-TWA are, therefore, well correlated with LC₅₀ values rather than LD₅₀ values, particularly with those in rats. High correlations between TLVs-STEL <i>vs</i>. LC₅₀s were also obtained, as had been expected before calculation. The equation: TLV-TWA=10^b×(LC₅₀)^a can be obtained from these plottings, where the values a and b are taken from each linear regression line. TLV-TWA for each chemical can be calculated by using LC₅₀ and the equation. The upper and lower 95% confidence limits for calculated TLV-TWA were TLV-TWA (calculated from LC₅₀)×22.9 and TLV-TWA (calculated)/22.9, respectively, where LC₅₀ for rats expressed in ppm×hr was used.
• DOI: 10.2486/indhealth.37.22
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: The correlations of lethal doses of various industrial chemicals for rats and mice with occupational exposure limit values were investigated. 50% lethal dose (LD₅₀) values obtained by oral (p.o.) and intraperitoneal (i.p.) injection and 50% lethal concentration (LC₅₀) values obtained by inhalation exposure were collected from Registry of Toxic Effects of Chemical Substances (RTECS). Threshold Limit Value (Time-Weighted Average) (TLVs-TWA) and Threshold Limit Value (Short Term Exposure Limit) (TLVs-STEL) recommended by American Conference of Governmental Industrial Hygienists (ACGIH) were used as exposure limits. TLVs-TWA or TLVs-STEL and LD₅₀ or LC₅₀ values obtained for the rats were plotted on logarithmic scales on the ordinate and abscissa, respectively. High correlations were obtained between these parameters. The order of correlations was: TLVs-STEL <i>vs</i>. LC₅₀s>TLVs-TWA <i>vs</i>. LC₅₀s>TLVs-TWA <i>vs</i>. LD₅₀s i.p.>TLVs <i>vs</i>. LD₅₀s p.o. The same calculations for the relationship between TLVs and lethal doses in mice were also performed. The order of the three types of correlations was same as that of the rats; however, correlation coefficients for TLVs-STEL <i>vs</i>. LC₅₀s and for TLVs-TWA <i>vs</i>. LC₅₀s obtained in mice were smaller than those in rats. TLVs-TWA are, therefore, well correlated with LC₅₀ values rather than LD₅₀ values, particularly with those in rats. High correlations between TLVs-STEL <i>vs</i>. LC₅₀s were also obtained, as had been expected before calculation. The equation: TLV-TWA=10^b×(LC₅₀)^a can be obtained from these plottings, where the values a and b are taken from each linear regression line. TLV-TWA for each chemical can be calculated by using LC₅₀ and the equation. The upper and lower 95% confidence limits for calculated TLV-TWA were TLV-TWA (calculated from LC₅₀)×22.9 and TLV-TWA (calculated)/22.9, respectively, where LC₅₀ for rats expressed in ppm×hr was used.
• DOI: 10.2486/indhealth.37.22; https://doi.org/10.2486/indhealth.37.22
• 関連情報（URI）: http://id.ndl.go.jp/bib/4682575; https://ndlsearch.ndl.go.jp/books/R000000004-I4682575; https://www.jstage.jst.go.jp/article/indhealth1963/37/1/37_1_22/_pdf
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; PubMed; https://pubmed.ncbi.nlm.nih.gov; CiNii Articles
• 書誌ID（NDLBibID）: 4682575; http://id.ndl.go.jp/bib/4682575
• NII論文ID: 130003550872; 40005265595