The Role of Apaf-1 in Programmed Cell Death: From Worm to Tumor (Physiological and Pathological Roles of Cell Death)
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- 資料種別
- 記事
- 著者・編者
- Hiroshi Yoshida
- 著者標目
- タイトル（掲載誌）
- Cell Structure and Function
- 巻号年月日等（掲載誌）
- 28(1) 2003.2
- 掲載巻
- 28
- 掲載号
- 1
- 掲載ページ
- 3～9
- 掲載年月日（W3CDTF）
- 2003-02
- ISSN（掲載誌）
- 0386-7196
- ISSN-L（掲載誌）
- 0386-7196
- 出版事項（掲載誌）
- Kyoto : Japan Society for Cell Biology
- 出版地（国名コード）
- JP
- 本文の言語コード
- eng
- NDLC
- 対象利用者
- 一般
- 所蔵機関
- 国立国会図書館
- 請求記号
- Z53-V38
- 連携機関・データベース
- 国立国会図書館 : 国立国会図書館雑誌記事索引
- 書誌ID（NDLBibID）
- 6487134
- 整理区分コード
- 632
- 要約等
- Apoptosis or programmed cell death is an important process to eliminate unnecessary or hazardous cells. Apaf-1, a mammalian homologue of CED-4 of <i>C. elegans</i>, is the essential adaptor molecule in the mitochondrial pathway of apoptosis. Mice lacking Apaf-1 show accumulation of neurons in the developing central nervous system due to reduced apoptosis. Apaf-1-deficient cells are remarkably resistant to various apoptotic stimuli. Apaf-1-mediated apoptosis plays a role in the prevention of tumorigenesis. However, Apaf-1-independent cell death pathways are also indicated. In this review, we will summarize what has been learned about the role of Apaf-1 by biochemical and genetical approaches.<br>
- DOI
- 10.1247/csf.28.3
- オンライン閲覧公開範囲
- インターネット公開
- 連携機関・データベース
- 科学技術振興機構 : J-STAGE
- 要約等
- Apoptosis or programmed cell death is an important process to eliminate unnecessary or hazardous cells. Apaf-1, a mammalian homologue of CED-4 of <i>C. elegans</i>, is the essential adaptor molecule in the mitochondrial pathway of apoptosis. Mice lacking Apaf-1 show accumulation of neurons in the developing central nervous system due to reduced apoptosis. Apaf-1-deficient cells are remarkably resistant to various apoptotic stimuli. Apaf-1-mediated apoptosis plays a role in the prevention of tumorigenesis. However, Apaf-1-independent cell death pathways are also indicated. In this review, we will summarize what has been learned about the role of Apaf-1 by biochemical and genetical approaches.<br>
- DOI
- 10.1247/csf.28.3
- オンライン閲覧公開範囲
- インターネット公開
- 関連情報（URI）
- 参照
- Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosisProgrammed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous systemDevelopmental defects and tumor predisposition in Rb mutant miceCytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced ApoptosisThe C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzymeThe Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis systemCaspase-Independent Cell Death and Mitochondrial Disruptions Observed in the Apaf1-Deficient CellsThe fly caspasesAn APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9A model for p53-induced apoptosisBcl-xL Regulates the Membrane Potential and Volume Homeostasis of MitochondriaApoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosomePrevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria BlockedWD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 ActivationDefective Cytochrome c-dependent Caspase Activation in Ovarian Cancer Cell Lines due to Diminished or Absent Apoptotic Protease Activating Factor-1 ActivityAdult Apaf-1-Deficient Mice Exhibit Male InfertilityApaf-1 protein deficiency confers resistance to cytochromec–dependent apoptosis in human leukemic cellsGenetic control of programmed cell death in the nematode C. elegansApaf-1 and Caspase-9 in p53-Dependent Apoptosis and Tumor InhibitionDebcl, a Proapoptotic Bcl-2 Homologue, Is a Component of the <i>Drosophila melanogaster</i> Cell Death Machineryp53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian DevelopmentMitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarizationAltered Cytochrome c Display Precedes Apoptotic Cell Death in <i>Drosophila </i>Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome cEssential Role of Voltage-Dependent Anion Channel in Various Forms of Apoptosis in Mammalian CellsMolecular characterization of mitochondrial apoptosis-inducing factorInactivation of the apoptosis effector Apaf-1 in malignant melanomaEpistatic and independent functions of Caspase-3 and Bcl-X <sub>L</sub> in developmental programmed cell deathEarly ontogeny of the secondary proliferative population of the embryonic murine cerebral wallWidespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex<i>Apaf-1</i> deficiency and neural tube closure defects are found in <i>fog</i> miceInterdigital cell death can occur through a necrotic and caspase-independent pathwayBcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDACCytochrome c and dATP-mediated Oligomerization of Apaf-1 Is a Prerequisite for Procaspase-9 ActivationEssential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changesApoptotic Molecular Machinery: Vastly Increased Complexity in Vertebrates Revealed by Genome ComparisonsThe Apoptotic Protease-Activating Factor 1-Mediated Pathway of Apoptosis Is Dispensable for Negative Selection of ThymocytesMitochondrial permeability transition in apoptosis and necrosisApaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3The Fas Death FactorTumor suppressor p53 is a direct transcriptional activator of the human bax geneDifferential requirement for Apaf1 and Bcl-XL in the regulation of programmed cell death during developmentThe cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wallCytochrome c Promotes Caspase-9 Activation by Inducing Nucleotide Binding to Apaf-1The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of ApoptosisApoptotic Protease Activating Factor 1 (Apaf-1)–Independent Cell Death Suppression by Bcl-2Programmed Cell Death in Animal DevelopmentApaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain DevelopmentCytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease CascadeDrosophila Pro-apoptotic Bcl-2/Bax Homologue Reveals Evolutionary Conservation of Cell Death MechanismsCaenorhabditis elegans gene ced-9 protects cells from programmed cell deathEndonuclease G is an apoptotic DNase when released from mitochondriaBcl-2 proteins: regulators of apoptosis or of mitochondrial homeostasis?Differential Requirement for Caspase 9 in Apoptotic Pathways In VivoFrameshift mutations in Fas, Apaf-1, and Bcl-10 in gastro-intestinal cancer of the microsatellite mutator phenotypeReduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9Autoactivation of Procaspase-9 by Apaf-1-Mediated OligomerizationDecreased apoptosis in the brain and premature lethality in CPP32-deficient miceProteases to die forRegulation of Apoptotic Protease Activating Factor-1 Oligomerization and Apoptosis by the WD-40 Repeat Region
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- 国立情報学研究所 : CiNii Research
- 提供元機関・データベース
- Japan Link Center雑誌記事索引データベースCrossrefPubMedCiNii ArticlesCiNii Articles
- 書誌ID（NDLBibID）
- 6487134
- NII論文ID
- 13000405382750000775056