ウサギ耳動脈におけるプリン作動性ノルエピネフリン遊離促進機構に関する研究

• 資料種別: 記事
• タイトル: ウサギ耳動脈におけるプリン作動性ノルエピネフリン遊離促進機構に関する研究
• 著者・編者: 野澤(石井) 玲子; 篠塚 和正; 国友 勝 他
• 著者標目: 野澤(石井) 玲子; 篠塚 和正; 国友 勝
• タイトル（掲載誌）: 薬学雑誌 = Journal of the Pharmaceutical Society of Japan / 日本薬学会 編
• 巻号年月日等（掲載誌）: 119(6) 1999.06
• 掲載巻: 119
• 掲載号: 6
• 掲載ページ: 417～428
• 掲載年月日（W3CDTF）: 1999-06
• ISSN（掲載誌）: 0031-6903
• ISSN-L（掲載誌）: 0031-6903
• 出版事項（掲載誌）: 東京 : 日本薬学会
• 出版地（国名コード）: JP
• 本文の言語コード: jpn
• NDLC: ZS51
• 対象利用者: 一般
• 所蔵機関: 国立国会図書館
• 請求記号: Z19-411
• 連携機関・データベース: 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• 書誌ID（NDLBibID）: 4741023; http://id.ndl.go.jp/bib/4741023
• 整理区分コード: 632

• 要約等: The purinergic modulation of the release of norepinephrine (NE) from sympathetic nerves in the rabbit ear artery was investigated. Methoxamine, an α<SUB>1</SUB>-adrenoceptor agonist, enhanced the NE-release by electrical stimulation (ES) and released large amounts of adenyl purines (ATP, ADP, AMP and adenosine) from the endothelium. Both actions of methoxamine were blocked by prazosin. In addition, the enhancement of the NE-release by methoxamine was abolished by 8-sulfophenyl theophylline (8SPT), a P1-purinoceptor antagonist. These findings indicated that the endogenous purines and purinoceptors participate in the facilitation of NE-release by α<SUB>1</SUB>-adrenoceptor stimulation. P1-Purinoceptor agonists, such as adenosine and 2-chloroadenosine, and P2-purinoceptor agonists, such as ATP and β, γ-methylene ATP (βγ-mATP), enhanced the ES-evoked NE-release. This enhancement was antagonized not only by the P1-purinoceptor antagonist, 8SPT, but also by the P2-purinoceptor desensitizing agent, α, β-methylene ATP. A phosphodiesterase inhibitor, Ro20-1724 potentiates the enhancement of NE-release by βγ-mATP. On the other hand, an adenylate cyclase inhibitor, SQ22536, inhibited the enhancement of NE-release by βγ-mATP. These findings suggested that prejunctional facilitatory purinoceptors exist on the adrenergic nerves of the rabbit ear artery. This receptor may be coupled to adenylate cyclase and is different from well-known P1 and P2 purinoceptors. In the rabbit ear artery, adrenergic neurotransmission may be regulated by endogenous ATP and its metabolites via prejunctional facilitatory purinoceptors, which were initiated by α<SUB>1</SUB>-adrenoceptor stimulation; i.e. transsynaptic regulation of neurotransmission.
• DOI: 10.1248/yakushi1947.119.6_417
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• 要約等: The purinergic modulation of the release of norepinephrine (NE) from sympathetic nerves in the rabbit ear artery was investigated. Methoxamine, an α<SUB>1</SUB>-adrenoceptor agonist, enhanced the NE-release by electrical stimulation (ES) and released large amounts of adenyl purines (ATP, ADP, AMP and adenosine) from the endothelium. Both actions of methoxamine were blocked by prazosin. In addition, the enhancement of the NE-release by methoxamine was abolished by 8-sulfophenyl theophylline (8SPT), a P1-purinoceptor antagonist. These findings indicated that the endogenous purines and purinoceptors participate in the facilitation of NE-release by α<SUB>1</SUB>-adrenoceptor stimulation. P1-Purinoceptor agonists, such as adenosine and 2-chloroadenosine, and P2-purinoceptor agonists, such as ATP and β, γ-methylene ATP (βγ-mATP), enhanced the ES-evoked NE-release. This enhancement was antagonized not only by the P1-purinoceptor antagonist, 8SPT, but also by the P2-purinoceptor desensitizing agent, α, β-methylene ATP. A phosphodiesterase inhibitor, Ro20-1724 potentiates the enhancement of NE-release by βγ-mATP. On the other hand, an adenylate cyclase inhibitor, SQ22536, inhibited the enhancement of NE-release by βγ-mATP. These findings suggested that prejunctional facilitatory purinoceptors exist on the adrenergic nerves of the rabbit ear artery. This receptor may be coupled to adenylate cyclase and is different from well-known P1 and P2 purinoceptors. In the rabbit ear artery, adrenergic neurotransmission may be regulated by endogenous ATP and its metabolites via prejunctional facilitatory purinoceptors, which were initiated by α<SUB>1</SUB>-adrenoceptor stimulation; i.e. transsynaptic regulation of neurotransmission.
• DOI: 10.1248/yakushi1947.119.6_417; https://doi.org/10.1248/yakushi1947.119.6_417; 10.1002/chin.199940267; https://doi.org/10.1002/chin.199940267
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（URI）: http://id.ndl.go.jp/bib/4741023; https://ndlsearch.ndl.go.jp/books/R000000004-I4741023; https://www.jstage.jst.go.jp/article/yakushi1947/119/6/119_6_417/_pdf; https://search.jamas.or.jp/link/ui/1999226900
• 連携機関・データベース: 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• 提供元機関・データベース: Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; Crossref; https://www.crossref.org; CiNii Articles
• 書誌ID（NDLBibID）: 4741023; http://id.ndl.go.jp/bib/4741023
• NII論文ID: 110003648749