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Hyaluronan Tetrasaccharides Penetrate into the Skin by Passive Diffusion and Contribute to Skin Health
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Hyaluronan Tetrasaccharides Penetrate into the Skin by Passive Diffusion and Contribute to Skin Health
- 資料種別
- 記事
- 著者
- Takagi Yutakaほか
- 出版者
- The Pharmaceutical Society of Japan
- 出版年
- 2025-04-01
- 資料形態
- デジタル
- 掲載誌名
- Chem. Pharm. Bull. 73 4
- 掲載ページ
- p.284-290
資料詳細
要約等:
- <p>Hyaluronan (HA) is a commonly used material in cosmetics and pharmaceuticals because of its various pharmacological activities. However, because of...
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デジタル
- 資料種別
- 記事
- 出版年月日等
- 2025-04-01
- 出版年(W3CDTF)
- 2025-04-01
- タイトル(掲載誌)
- Chem. Pharm. Bull.
- 巻号年月日等(掲載誌)
- 73 4
- 掲載巻
- 73
- 掲載号
- 4
- 掲載ページ
- 284-290
- 掲載年月日(W3CDTF)
- 2025-04-01
- ISSN(掲載誌)
- 00092363
- 出版事項(掲載誌)
- The Pharmaceutical Society of Japan
- 本文の言語コード
- en
- 対象利用者
- 一般
- 標準番号(その他)
- PMID : 40175107
- DOI
- 10.1248/cpb.c23-00909
- 参照
- Therapeutic potential of hyaluronan oligosaccharides for bone metastasis of breast cancerHigh-Molecular-Weight Hyaluronan Is a Hippo Pathway Ligand Directing Cell Density-Dependent Growth Inhibition via PAR1bHyaluronan: Metabolism and FunctionCD44v10 interaction with Rho‐kinase (ROK) activates inositol 1,4,5‐triphosphate (IP<sub>3</sub>) receptor‐mediated Ca<sup>2+</sup> signaling during hyaluronan (HA)‐induced endothelial cell migrationCeramide biosynthesis in keratinocyte and its role in skin functionCD44: The hyaluronan receptorHyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44.In Vivo Stimulation of De Novo Collagen Production Caused by Cross-linked Hyaluronic Acid Dermal Filler Injections in Photodamaged Human SkinHyaluronan in the lymphatics: The key role of the hyaluronan receptor LYVE-1 in leucocyte traffickingLung Hyaluronasome: Involvement of Low Molecular Weight Ha (Lmw-Ha) in Innate ImmunityHyaluronan Oligosaccharides Improve Rosacea-Like Phenotype through Anti-Inflammatory and Epidermal Barrier-Improving EffectsCurcumin entrapped hyaluronan containing niosomes: preparation, characterisation and <i>in vitro/in vivo</i> evaluationHigh, but not low, molecular weight hyaluronan prevents T-cell-mediated liver injury by reducing proinflammatory cytokines in miceBiology of fetal wound healing: Hyaluronate receptor expression in fetal fibroblastsNiosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and AntioxidantCD44 Assists the Topical Anti-Psoriatic Efficacy of Curcumin-Loaded Hyaluronan-Modified Ethosomes: A New Strategy for Clustering Drug in Inflammatory SkinStarvation reduces hyaluronan synthesis by suppressing TGF-β1/IGF-I signaling in rat skinOral administration of hyaluronic acid to improve skin conditions via a randomized double‐blind clinical testFacial rejuvenation using a microneedle‐based device with a revitalizing solution and free hyaluronic acidEnzymatic Production of Low-Molecular-Weight Hyaluronan and Its Oligosaccharides: A Review and ProspectsHuman Skin Aging and the Anti-Aging Properties of RetinolThe most promising microneedle device: present and future of hyaluronic acid microneedle patchImmunochemical Confirmation of the Primary Structure of Streptococcal Hyaluronan Synthase and Synthesis of High Molecular Weight Product by the Recombinant EnzymeHyaluronic acid binding to CD44S is indiscriminate of molecular weightZona pellucida-binding protein 2 (ZPBP2) and several proteins containing BX7B motifs in human sperm may have hyaluronic acid binding or recognition propertiesThe Use of Sodium Hyaluronate (Healon®) in Human Anterior Segment SurgeyHyaluronan oligosaccharide treatment of chondrocytes stimulates expression of both HAS-2 and MMP-3, but by different signaling pathwaysHyaluronic acid: A key molecule in skin agingThe skin barrier in healthy and diseased stateHyaluronan SynthasesHyaluronan in skinInduction of IL-12 and chemokines by hyaluronan requires adhesion-dependent priming of resident but not elicited macrophages.Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancerHyaluronic Acid-Based Dissolving Microneedle Patch Loaded with Methotrexate for Improved Treatment of PsoriasisAntiwrinkle efficacy of 1‐ethyl‐<i>β</i>‐<i>N</i>‐acetylglucosaminide, an inducer of epidermal hyaluronan productionAccelerated human epidermal turnover driven by increased hyaluronan productionThe CD147‐HYALURONAN Axis in CancerPreparation and characterization of dissolving hyaluronic acid composite microneedles loaded micelles for delivery of curcuminClinical Applications of HyaluronidaseThe hyaluronic acid-rich node and duct system is a structure organized for innate immunity and mediates the local inflammationIontophoresis for the cutaneous delivery of nanoentraped drugsTherapeutic effects of high molecular weight hyaluronic acid in severe <i>Pseudomonas aeruginosa</i> pneumonia in ex vivo perfused human lungsHyaluronic acid and HA-modified cationic liposomes for promoting skin penetration and retentionHyaluronan network: a driving force in cancer progressionEffects of hyaluronic acid injected using the mesogun injector with stamp‐type microneedle on skin hydrationA Connecting Link between Hyaluronan Synthase 3-Mediated Hyaluronan Production and Epidermal FunctionTransdermal Delivery of Hyaluronan Tetrasaccharide by Constant Current IontophoresisHyaluronan-based Multifunctional Nano-carriers for Combination Cancer TherapyRole of the Hyaluronan Receptor, Stabilin-2/HARE, in Health and DiseaseUnique combination of hyaluronic acid and amino acids in the management of patients with a wide range of moderate‐to‐severe chronic wounds: Evidence from international clinical practiceEngineering Hyaluronic Acid for the Development of New Treatment Strategies for Osteoarthritis<scp>2‐kDa</scp> hyaluronan ameliorates human facial wrinkles through increased dermal collagen density related to promotion of collagen remodelingMicroneedle and iontophoresis mediated delivery of methotrexate into and across healthy and psoriatic skinInvolvement of hyaluronan and CD44 in cancer and viral infectionsHyaluronan-CD44 Interaction with Rac1-dependent Protein Kinase N-γ Promotes Phospholipase Cγ1 Activation, Ca2+ Signaling, and Cortactin-Cytoskeleton Function Leading to Keratinocyte Adhesion and DifferentiationGlycosaminoglycans and their proteoglycans: host‐associated molecular patterns for initiation and modulation of inflammationThe effects of hyaluronan on matrix metalloproteinase-3 (MMP-3), interleukin-1β(IL-1β), and tissue inhibitor of metalloproteinase-1 (TIMP-1) gene expression during the development of osteoarthritisSignaling Properties of Hyaluronan ReceptorsBranched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skinHyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent clinical studiesRevisiting the hallmarks of cancer: The role of hyaluronanUse of chromatographic and electrophoretic tools for assaying elastase, collagenase, hyaluronidase, and tyrosinase activityOral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled StudyFree radical scavenging properties of mannitol and its role as a constituent of hyaluronic acid fillers: a literature reviewAn Overview of Methods to Characterize Skin Type: Focus on Visual Rating Scales and Self-Report InstrumentsHyaluronan polymeric micelles for topical drug deliverySkin electroporation for transdermal drug delivery: Electrical measurements, numerical model and molecule deliveryThe use of sodium hyaluronate (Healon) in the treatment of complicated cases of retinal detachmentPermeation of hyaluronan tetrasaccharides through hairless mouse skin: an in vitro and in vivo studyDissolving microneedle with high molecular weight hyaluronic acid to improve skin wrinkles, dermal density and elasticityReceptor for hyaluronan‐mediated motility ( <scp>RHAMM</scp> ) defines an invasive niche associated with tumor progression and predicts poor outcomes in breast cancer patientsSelf-assembled hyaluronic acid nanoparticles for osteoarthritis treatmentEfficacy and Safety of Two Resilient Hyaluronic Acid Fillers in the Treatment of Moderate-to-Severe Nasolabial Folds: A 64-Week, Prospective, Multicenter, Controlled, Randomized, Double-Blinded, and Within-Subject StudySulfated modification of hyaluronan tetrasaccharide enhances its antitumor activity on human lung adenocarcinoma A549 cells in vitro and in vivoHyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacinAnti‐aging and filling efficacy of six types hyaluronic acid based dermo‐cosmetic treatment: double blind, randomized clinical trial of efficacy and safetyProteoglycans and Hyaluronan in Morphogenesis and DifferentiationHYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblastsPhosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesisAge-Related Changes in Pericellular Hyaluronan Organization Leads to Impaired Dermal Fibroblast to Myofibroblast DifferentiationHyaluronan oligosaccharide–induced activation of transcription factors in bovine articular chondrocytesImmunologic Roles of Hyaluronan in Dermal Wound HealingThe membrane receptor CD44: novel insights into metabolismUV filter entrapment in mesoporous silica hydrogel for skin protection against UVA with minimization of percutaneous absorptionHyaluronan tetrasaccharides stimulate ceramide production through upregulated mRNA expression of ceramide synthesis-associated enzymesExtracellular ATP activates hyaluronan synthase 2 (<i>HAS2</i>) in epidermal keratinocytes via P2Y2, Ca2+ signaling, and MAPK pathwaysHyaluronic Acid-Mediated Drug Delivery System Targeting for Inflammatory Skin Diseases: A Mini ReviewHAS3-induced extracellular vesicles from melanoma cells stimulate IHH mediated c-Myc upregulation via the hedgehog signaling pathway in target cellsHyaluronic acid-containing ethosomes as a potential carrier for transdermal drug deliveryHyaluronic acid-alendronate conjugate: A macromolecular drug delivery system for intra-articular treatment of osteoarthritisCD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferationThe Hyaluronan/CD44 Axis: A Double-Edged Sword in CancerPLGA Nanoparticles Grafted with Hyaluronic Acid to Improve Site-Specificity and Drug Dose Delivery in Osteoarthritis NanotherapyEnhanced hyaluronic acid production in <i>Streptococcus zooepidemicus</i> by an optimized culture medium containing hyaluronidase inhibitorBiodistribution and intracellular localization of hyaluronan and its nanogels. A strategy to target intracellular S. aureus in persistent skin infectionsTargeting LAYN inhibits colorectal cancer metastasis and tumor-associated macrophage infiltration induced by hyaluronan oligosaccharidesHyaluronic acid with antioxidants improve wound healing in ratsIntraarticular Hyaluronic Acid Preparations for Knee Osteoarthritis: Are Some Better Than Others?AN ANIMAL MODEL OF SOLAR‐AGED SKIN: HISTOLOGICAL, PHYSICAL, and VISIBLE CHANGES IN UV‐IRRADIATED HAIRLESS MOUSE SKIN*Importance of intercellular lipids in water-retention properties of the stratum corneum: induction and recovery study of surfactant dry skinUnderstanding Premature Skin AgingInhibition of tumor growthin vivo by hyaluronan oligomersAggregation of Cartilage ProteoglycansMolecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes.Hyaluronic acid in human articular cartilage. Age-related changes in content and sizeLipid content and lipid type as determinants of the epidermal permeability barrier.Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages.Clinical Implications of Aging SkinHyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applicationsCD44-dependent Intracellular and Extracellular Catabolism of Hyaluronic Acid by Hyaluronidase-1 and -2HYALURONIC ACID IN CUTANEOUS INTRINSIC AGINGHyaluronan Oligosaccharides Inhibit Anchorage-independent Growth of Tumor Cells by Suppressing the Phosphoinositide 3-Kinase/Akt Cell Survival PathwayHyaluronan <sup>1</sup>Mammalian hyaluronan synthases: investigation of functional relationships <i>in vivo</i>Hyaluronan catabolism: a new metabolic pathwaySkin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damageHyaluronate in VasculogenesisHigh molecular weight hyaluronic acid inhibits advanced glycation endproduct‐induced NF‐κB activation and cytokine expressionEffect of hyaluronan tetrasaccharides on epidermal differentiation in normal human epidermal keratinocytesEnhanced transdermal lymphatic drug delivery of hyaluronic acid modified transfersomes for tumor metastasis therapyThe influence of age and sex on skin thickness, skin collagen and densityCharacterization and Molecular Evolution of a Vertebrate Hyaluronan Synthase Gene FamilyA Possible Function of Structural Lipids in the Water-Holding Properties of the Stratum CorneumHyaluronan–CD44 Interaction Stimulates Keratinocyte Differentiation, Lamellar Body Formation/Secretion, and Permeability Barrier HomeostasisDecreased Collagen Production in Chronologically Aged SkinHyaluronan: its nature, distribution, functions and turnoverHyaluronan Fragments Stimulate Endothelial Recognition of Injury through TLR4Hyaluronan–CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9Angiogenesis Induced by Degradation Products of Hyaluronic AcidThe 500 Dalton rule for the skin penetration of chemical compounds and drugsEvidence for structural changes in dermatan sulfate and hyaluronic acid with agingSelective Recovery of Deranged Water-Holding Properties by Stratum Corneum LipidsEffect of hyaluronic acid on postoperative intraperitoneal adhesion formation in the rat modelChanges in the Ceramide Profile of Atopic Dermatitis PatientsApplications and delivery mechanisms of hyaluronic acid used for topical/transdermal delivery – A reviewHuman stratum corneum lipids: characterization and regional variationsThe Cell Adhesion Molecule, GP116, Is a New CD44 Variant (ex14/v10) Involved in Hyaluronic Acid Binding and Endothelial Cell ProliferationTransdermal delivery of relatively high molecular weight drugs using novel self-dissolving microneedle arrays fabricated from hyaluronic acid and their characteristics and safety after application to the skinEpidermal sphingolipids: Metabolism, function, and roles in skin disordersCeramides and Skin FunctionChronic Ultraviolet B Irradiation Causes Loss of Hyaluronic Acid from Mouse Dermis Because of Down-Regulation of Hyaluronic Acid SynthasesNLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to InjuryContact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid DegradationTHE POLYSACCHARIDE OF THE VITREOUS HUMORRecognition of Hyaluronan Released in Sterile Injury Involves a Unique Receptor Complex Dependent on Toll-like Receptor 4, CD44, and MD-2A new strategy for the passive skin delivery of nanoparticulate, high molecular weight hyaluronic acid prepared by a polyion complex methodRegulation of epidermal sphingolipid synthesis by permeability barrier function.Highlighted Paper selected by Editor-in-Chief : Supramolecular Complex of Methyl-β-cyclodextrin with Adamantane-Grafted Hyaluronic Acid as a Novel Antitumor AgentThe Effect of Sunscreen on Skin Elastase Activity Induced by Ultraviolet-A IrradiationThe Effect of Iontophoresis with and without Electroporation on the Penetration of High Molecular Compounds into the Stratum CorneumAnalysis of Acetylated Hyaluronic Acid in Moisturizing Lotion and Milk Lotion by HPLC with Fluorescence DetectionNon-invasive Intradermal Delivery of Hyaluronic Acid via Iontophoresis.
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- 提供元機関・データベース
- Japan Link CenterCrossrefPubMed