タイトル（掲載誌）Allergology International
一般注記Background: Respiratory syncytial virus (RSV) infection causes asthma-like symptoms in infants and young children. Although an increase in several cytokines in the airway during RSV infection has been reported, the mechanisms involved in airway inflammation are not fully understood. The aim of this study was to investigate the immunological deviation associated with airway inflammation by measuring cytokines and chemokine in the airway during RSV infection. Methods: One hundred and ten children under three years of age with respiratory symptoms were enrolled in this study from November 2004 through January 2005. NPAs were gently aspirated and analyzed with RSV antigen, thereafter the concentrations of IL-4, IL-10, IFN-γ, and RANTES were measured using an ELISA kit. We also investigated the prognosis of each child after 1 year by reference to clinical records or by interviews and re-evaluated the cytokine and chemokine levels. Results: In subjects 70 children were RSV positive and 40 were negative. Only four children were pediatrician diagnosed asthma when NPAs were collected. The levels of IL-4, IL-10, and RANTES were significantly higher in the RSV-positive patients than RSV-negative patients with P values at 0.0362, 0.0007, and 0.0047, respectively. In contrast, there was no significant difference in the levels of IFN-γ. Furthermore, there was a significant positive correlation between IL-10 and RANTES. RANTES levels in RSV-positive patients with wheeze were higher than in patients RSV-negative with wheeze. On the other hand in patients without wheeze RANTES was no difference between RSV-positive and RSV-negative. Whatever patients had wheeze or not, the levels of IL-10 in RSV-positive were higher than in RSV-negative. Conclusions: The increased production of IL-4, IL-10, and RANTES in the airway may play an important role in the pathophysiological mechanisms of RSV infection.
一次資料へのリンクURLhttps://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=20198&item_no=1&attribute_id=22&file_no=1
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）