Primary central nervous system lymphoma secretes monocyte chemoattractant protein 1

• 資料種別: 文書・図像類
• タイトル: Primary central nervous system lymphoma secretes monocyte chemoattractant protein 1
• 著者・編者: KITAI, Ryuhei; ISHISAKA, Kazuyo; SATO, Kazufumi; SAKUMA, Takahiro; YAMAUCHI, Takahiro; IMAMURA, Yoshiaki; MATSUMOTO, Hideki; KUBOTA, Toshihiko
• 著者標目: KITAI, Ryuhei; ISHISAKA, Kazuyo; SATO, Kazufumi; SAKUMA, Takahiro; YAMAUCHI, Takahiro; IMAMURA, Yoshiaki; MATSUMOTO, Hideki; KUBOTA, Toshihiko
• 出版事項: Springer
• 出版年月日等: 2007-03
• 出版年（W3CDTF）: 2007-03
• タイトル（掲載誌）: Medical Molecular Morphology
• 巻号年月日等（掲載誌）: 40 1
• 掲載巻: 40
• 掲載号: 1
• 掲載ページ: 18-22
• ISSN（掲載誌）: ISSN : 1860-1480
• 本文の言語コード: eng
• 件名標目: Primary CNS lymphoma; Chemokine; MCP-1
• 対象利用者: 一般
• 一般注記: The majority of primary central nervous system lymphomas (PCNSL) are diffuse large B-cell lymphomas. Histologically, reactive T lymphocytes and monohistiocytic cells are found within PCNSL tissue. To clarify the mechanisms of the cellular infiltration, the presence of monocyte chemoattractant protein (MCP-1) was investigated in biopsy samples of 19 cases of PCNSL by means of immunohistochemical staining, double staining with a confocal laser microscope, and Western blot analysis. MCP-1 expression was observed in all PCNSL immunohistochemically. Western blot analysis showed that the concentration of MCP-1 in PCNSL was as high as that in a metastatic brain tumor. In normal brain tissue, MCP-1 was not detected. Confocal laser microscope revealed MCP-1 signals were present in the cells with CD20, a B-cell marker. We concluded that lymphoma cells produced MCP-1, which is an additional cytokine involved in the pathogenesis of PCNSL.
• オンライン閲覧公開範囲: 限定公開
• 関連情報（DOI）: 10.1007/s00795-006-0350-7
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 福井大学 : 福井大学学術機関リポジトリ