タイトル（掲載誌）INTERNATIONAL JOURNAL OF CARDIOLOGY
一般注記Background. Myocardial flow reserve (MFR) in the non-infarct-related area (NIRA) has been reported to be impaired after the onset of myocardial infarction (MI). The aim of this study was to determine whether microvascular dysfunction in the NIRA is related to left-ventricular remodeling after MI. Methods. We prospectively studied 17 patients who suffered their first single-vessel MI, and who underwent successful revascularization. The MFR in the NIRA was assessed quantitatively using ^13N-ammonia positron emission tomography within 2 weeks after the onset. Peak creatinine kinase and the defect score on ^<99m>Tc-tetrofosmin myocardial perfusion imaging were used as an index of the severity of MI. The left-ventricular end-diastolic volume index (LVEDVI) was calculated using left ventriculography at 1 month and 6 months after the onset. Results. Patients with severely impaired MFR (< 2.09) had higher peak creatinine kinase values (6,000 ± 5,485 IU/L vs. 2,250 ± 1,950 IU/L, p = 0.0081), defect scores (16.3 ± 5.9 vs. 7.9 ± 6.5, p = 0.0404), and LVEDVI at 1 month (125.6 ± 34.4 mL/m^2 vs. 82.8 ± 17.7 mL/m^2, p = 0.0036) than those with mildly impaired MFR (〓 2.09). Moreover, the differences of LVEDVI between the 2 groups persisted over 6 months (133.3 ± 43.6 mL/m^2 vs. 89.5 ± 17.3 mL/m^2, p = 0.0078). The MFR in the NIRA correlated inversely with the LVEDVI at 1 month and 6 months (r = -0.590, p = 0.0127 and r = -0.729, p = 0.0031, respectively). Conclusions. These data indicate that microvascular impairment in the NIRA might have contributed to left-ventricular remodeling after MI.
一次資料へのリンクURLhttps://u-fukui.repo.nii.ac.jp/?action=repository_action_common_download&item_id=19887&item_no=1&attribute_id=22&file_no=1
関連情報（DOI）10.1016/j.ijcard.2007.04.042
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）