Role of CD44 expression in non-tumor tissue on intrahepatic recurrence of hepatocellular carcinoma

• 資料種別: 博士論文
• タイトル: Role of CD44 expression in non-tumor tissue on intrahepatic recurrence of hepatocellular carcinoma
• 著者・編者: Tovuu, Lkhagva-Ochir; Imura, Satoru; Utsunomiya, Tohru; Morine, Yuji; Ikemoto, Tetsuya; Arakawa, Yusuke; Mori, Hiroki; Hanaoka, Jun; Kanamoto, Mami; Sugimoto, Koji; Iwahashi, Shuichi; Saito, Yu; Yamada, Shinichiro; Asanoma, Michihito; Miyake, Hidenori; Shimada, Mitsuo
• 著者標目: Tovuu, Lkhagva-Ochir; Imura, Satoru; Utsunomiya, Tohru; Morine, Yuji; Ikemoto, Tetsuya; Arakawa, Yusuke; Mori, Hiroki; Hanaoka, Jun; Kanamoto, Mami; Sugimoto, Koji; Iwahashi, Shuichi; Saito, Yu; Yamada, Shinichiro; Asanoma, Michihito; Miyake, Hidenori; Shimada, Mitsuo
• 出版事項: Springer nature
• 出版年月日等: 2012-06-16
• 出版年（W3CDTF）: 2012-06-16
• 並列タイトル等: 肝細胞癌の肝内再発における非癌部でのCD44発現の役割; CD44 expression in HCC
• タイトル（掲載誌）: International Journal of Clinical Oncology
• 巻号年月日等（掲載誌）: 18 4
• 掲載巻: 18
• 掲載号: 4
• 掲載ページ: 651-656
• ISSN（掲載誌）: ISSN : 1341-9625; ISSN : 1437-7772
• 授与機関名: 徳島大学
• 授与年月日: 2014-03-24
• 報告番号: 甲第2669号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: hepatocellular carcinoma; CD44; prognostic factor; non tumor tissue
• 対象利用者: 一般
• 一般注記: Background: CD44 is well known to be one of the cancer stem cell markers and is a cell-surface glycoproteininvolved in cell-cell interactions, cell adhesion, and cell migration. We investigated the role of CD44 expression in both tumor and non-tumor tissues on recurrence of hepatocellular carcinoma (HCC). Methods: Forty-eight patients with HCC who underwent hepatic resection at our institution were enrolled in this study. CD44 expressions in both tumor and non-tumor tissues were examined using real time reverse transcription-polymerase chain reaction. The patients were divided into two groups: high and low gene-expression group, based on the CD44 expression level. We compared the clinicopathological factors between the high expression and low expression groups in both tumor and non-tumor tissues. Results: In the tumor tissues, the gene-expression levels of CD44 did not correlate with any clinicopathological parameters. The disease-free survival rate showed no significant difference between the two gourps. In non-tumor tissues, although there was no significant relationship between the CD44 expression levels and clinicopathological factors, disease-free survival rate in the CD44 low expression group was significantly better than that in the CD44 high expression group (p<0.05). In multivariate analysis, the risk factors in tumor recurrence were presence of microscopic portal invasion and high expression level of CD44. Conclusion: The CD44 expressions in the non-tumor tissues may predict HCC recurrence.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1007/s10147-012-0432-6
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/10/106069/2017092914463632021/LID201404221013.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/106069/20170929144636343977/LID201410281001.pdf fulltext