Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese

• 資料種別: 博士論文
• タイトル: Gene polymorphism of β-defensin-1 is associated with susceptibility to periodontitis in Japanese
• 著者・編者: Ikuta, Takahisa; Inagaki, Yuji; Tanaka, Kazuya; Saito, Tsuyoshi; Nakajima, Yukiko; Bando, Mika; Kido, Jun-ichi; Nagata, Toshihiko
• 著者標目: Ikuta, Takahisa; Inagaki, Yuji; Tanaka, Kazuya; Saito, Tsuyoshi; Nakajima, Yukiko; Bando, Mika; Kido, Jun-ichi; Nagata, Toshihiko
• 出版事項: Springer nature
• 出版年月日等: 2013-11-26
• 出版年（W3CDTF）: 2013-11-26
• 並列タイトル等: 日本人歯周病患者におけるβ-ディフェシン-１の遺伝子多型と疾患感受性に関する研究; β-defensin-1 SNPs in Japanese periodontitis
• タイトル（掲載誌）: Odontology
• 巻号年月日等（掲載誌）: 103 1
• 掲載巻: 103
• 掲載号: 1
• 掲載ページ: 66-74
• ISSN（掲載誌）: ISSN : 1618-1247; ISSN : 1618-1255
• 授与機関名: 徳島大学
• 授与年月日: 2014-03-24
• 報告番号: 甲第2689号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: periodontitis; SNP; β-defensin-1; lactoferrin; gingival crevicular fluid
• 対象利用者: 一般
• 一般注記: Background and Objective: Periodontitis is a multifactorial disease associated with genetic and environmental factors. Recent reports have shown that single-nucleotide polymorphisms (SNPs) are associated with susceptibility to common diseases such as not only diabetes and hypertension but also periodontitis. Although the oral cavity is continuously exposed to various pathogenic organisms, the oral conditions are well controlled by innate and acquired immune systems. Antimicrobial peptides (AMPs) play an important role in the innate immune system; however, the association of AMP-SNPs with periodontitis has not been fully elucidated. The aim of the present study was to investigate the relationship between AMP-SNPs and periodontitis in Japanese. Methods: One hundred and five Japanese subjects were recruited, which included 21 patients with aggressive, 28 with severe, 13 with moderate and 22 with mild periodontitis, as well as 21 age-matched healthy controls. Genomic DNA was isolated from peripheral blood in each subject. Genotypes of four reported SNPs of β-defensin-1 and lactoferrin genes (DEFB1: rs1799946, rs1800972 and rs11362; and LTF: rs1126478) were investigated using the PCR-Invader assay. Protein levels of AMP in gingival crevicular fluid (GCF) were quantified by ELISA. Results: Case-control studies revealed that the -44 CC genotype of DEFB1 (rs1800972) was associated with severe chronic periodontitis (odds ratio 4.15) and with combined severe and moderate chronic periodontitis (odds ratio 4.04). No statistical differences were found in other genotypes. The β-defensin-1 concentrations in GCF were significantly lower in the subjects with the -44 CC genotype of DEFB1 than in those without this genotype. No significant differences between GCF concentrations of AMPs and other genotypes were detected. Conclusion: The -44 CC genotype of the β-defensin-1 gene (DEFB1 rs1800972) may be associated with susceptibility to chronic periodontitis in Japanese.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1007/s10266-013-0139-9
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/10/106075/20170929145109683107/LID201404231001.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/106075/2017092914511076162/LID201404231002.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/106075/20170929145110425668/LID201606231001.pdf fulltext