Operator-bias-free Comparison of Quantitative Perfusion Maps Acquired with Pulsed-continuous Arterial Spin Labeling and Single-photon-emission Computed Tomography

• 資料種別: 博士論文
• タイトル: Operator-bias-free Comparison of Quantitative Perfusion Maps Acquired with Pulsed-continuous Arterial Spin Labeling and Single-photon-emission Computed Tomography
• 著者・編者: Iwanaga, Takashi; Harada, Masafumi; Kubo, Hitoshi; Funakoshi, Yasuhiro; Kunikane, Yamato; Matsuda, Tsuyoshi
• 著者標目: Iwanaga, Takashi; Harada, Masafumi; Kubo, Hitoshi; Funakoshi, Yasuhiro; Kunikane, Yamato; Matsuda, Tsuyoshi
• 出版事項: Japanese Society for Magnetic Resonance in Medicine
• 出版年月日等: 2014-12-01
• 出版年（W3CDTF）: 2014-12-01
• 並列タイトル等: 関心領域自動設定システムを用いた磁気共鳴動脈タギング撮像法と単一光子放射断層撮影における脳灌流定量画像の比較; Comparison of CBF between pCASL and SPECT
• タイトル（掲載誌）: Magnetic Resonance in Medical Sciences
• 巻号年月日等（掲載誌）: 13 4
• 掲載巻: 13
• 掲載号: 4
• 掲載ページ: 239-249
• ISSN（掲載誌）: ISSN : 1880-2206; ISSN : 1347-3182
• 授与機関名: 徳島大学
• 授与年月日: 2014-11-20
• 報告番号: 甲第2781号
• 学位: 博士（保健学）
• 本文の言語コード: eng
• 件名標目: arterial spin labeling; iodine-123-N-isopropyl-p-iodoamphetamine; pulsed continuous arterial spin labeling; regional cerebral blood flow; 3-dimensional stereotactic region-of-interest software
• 対象利用者: 一般
• 一般注記: Purpose: We compared the regional cerebral blood flow (rCBF) obtained by pulsed continuous arterial spin labeling (pCASL) and iodine-123-N-isopropyl-p-iodoamphetamine (IMP) single photon emission computed tomography (SPECT) using 3-dimensional stereotactic region-of-interest (ROI) software for automated definition of ROIs in anatomic regions of the brain. Methods: Thirteen patients with cerebrovascular occlusive disease and three with transient ischemic attacks underwent pCASL and IMP SPECT imaging. We compared rCBF values of each anatomic region and calculated the correlation coefficients between pCASL and IMP SPECT. We also calculated the asymmetry index (AI) using ROIs in contralateral regions of the hemispheres. Results: The rCBF values calculated from pCASL and IMP SPECT were comparable in most segments, but rCBF in the thalamus (P < 0.0001) and hippocampus (P = 0.0006) was significantly higher measured by pCASL than IMP SPECT. The correlation of rCBF between pCASL and IMP SPECT in the affected hemisphere (r = 0.50) tended to be lower than that in the normal hemisphere (r = 0.59), but not significantly different (P = 0.25). Moreover, there was a fixed bias for underestimation of rCBF by pCASL (P = 0.0047) in the affected hemisphere. The calculated AI showed a significant relationship between methods (r = 0.79, P < 0.0001). Conclusion: The rCBF obtained by pCASL had positive relationships with IMP SPECT. However, it should be considered that pCASL tends to have a weak relationship with IMP SPECT in some normal regions and regions affected by cerebrovascular occlusive disease.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2463/mrms.2013-0117
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/10/106376/20170929144546346107/LID201502041001.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/106376/20170929144547100295/LID201502041002.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/106376/20170929144547666607/LID201502041003.pdf fulltext