Improvement in diagnostic performance of the revised total testosterone measuring system in Japanese women with polycystic ovary syndrome

• 資料種別: 博士論文
• タイトル: Improvement in diagnostic performance of the revised total testosterone measuring system in Japanese women with polycystic ovary syndrome
• 著者・編者: Niki, Hirobumi; Matsuzaki, Toshiya; Kinouchi, Riyo; Iwasa, Takeshi; Kawami, Takako; Kato, Takeshi; Kuwahara, Akira; Irahara, Minoru
• 著者標目: Niki, Hirobumi; Matsuzaki, Toshiya; Kinouchi, Riyo; Iwasa, Takeshi; Kawami, Takako; Kato, Takeshi; Kuwahara, Akira; Irahara, Minoru
• 出版年月日等: 2014-02
• 出版年（W3CDTF）: 2014-02
• 並列タイトル等: テストステロン測定系の改良により日本女性における多嚢胞性卵巣症候群患者の診断効率は改善した; Diagnosis of PCOS by Revised T Assay
• タイトル（掲載誌）: The journal of medical investigation : JMI
• 巻号年月日等（掲載誌）: 61 1-2
• 掲載巻: 61
• 掲載号: 1-2
• 掲載ページ: 65-71
• ISSN（掲載誌）: ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2014-03-19
• 報告番号: 甲第2739号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: PCOS; testosterone; diagnosis; LH; assay
• 対象利用者: 一般
• 一般注記: Hyperandrogenemia has become an important factor in the diagnosis of polycystic ovary syndrome (PCOS), in Japan as well as Western countries, since the Japanese PCOS diagnostic criteria were revised in 2007. The revised electrochemiluminescence immunoassay (ECLIA) reagent for total testosterone (T) (ECLusys TESTO II ; New T assay), which has lower cross-reactivity with DHEA-S than the previous reagent (ECLusys TESTO I ; Old T assay), has recently been developed. We studied the improvement between New and Old T assays in regards to the diagnostic performance of serum T for patients with PCOS. Serum T levels were measured in both normal women (Control, n=92) and PCOS patients (n=86). The rate of elevated T using each kit was significantly higher in the PCOS group than in the Control group, and significantly higher using New T assay (38/86, 44.2%) compared with Old T assay (26/86, 30.2%). A significant correlation was found between T level and body mass index, but not LH level. Furthermore, higher detection rates of hormonal abnormalities were seen in PCOS patients using combined measurement of both T and LH (63/80) compared with single measurement of either T (37/80) or LH (36/80). Therefore, the serum T assay is essential for the diagnosis of PCOS, and New T assay combined with the LH assay may improve the diagnostic process for PCOS.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.61.65
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/10/109522/20190809163552436179/LID201405131003.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/10/109522/20190809163552760386/LID201503191001.pdf fulltext