Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

• 資料種別: 博士論文
• タイトル: Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus
• 著者・編者: Uddin, Md.Myn; Ohigashi, Izumi; Motosugi, Ryo; Nakayama, Tomomi; Sakata, Mie; Hamazaki, Jun; Nishito, Yasumasa; Rode, Immanuel; Tanaka, Keiji; Takemoto, Tatsuya; Murata, Shigeo; Takahama, Yousuke
• 著者標目: Uddin, Md.Myn; Ohigashi, Izumi; Motosugi, Ryo; Nakayama, Tomomi; Sakata, Mie; Hamazaki, Jun; Nishito, Yasumasa; Rode, Immanuel; Tanaka, Keiji; Takemoto, Tatsuya; Murata, Shigeo; Takahama, Yousuke
• 出版事項: Springer nature
• 出版年月日等: 2017-02-08
• 出版年（W3CDTF）: 2017-02-08
• 並列タイトル等: Foxn1−β5t転写制御軸は胸腺でのCD8陽性T細胞生成を制御する
• タイトル（掲載誌）: Nature Communications
• 巻号年月日等（掲載誌）: 8
• 掲載巻: 8
• 掲載ページ: 14419-
• ISSN（掲載誌）: ISSN : 2041-1723
• 授与機関名: 徳島大学
• 授与年月日: 2017-09-28
• 報告番号: 甲第3099号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: 胸腺; 胸腺上皮細胞; CD8陽性T細胞; 胸腺プロテアソーム; 転写制御
• 対象利用者: 一般
• 一般注記: The thymus is an organ that produces functionally competent T cells that protect us from pathogens and malignancies. Foxn1 is a transcription factor that is essential for thymus organogenesis; however, the direct target for Foxn1 to actuate thymic T-cell production is unknown. Here we show that a Foxn1-binding cis-regulatory element promotes the transcription of β5t, which has an essential role in cortical thymic epithelial cells to induce positive selection of functionally competent CD8+ T cells. A point mutation in this genome element results in a defect in β5t expression and CD8+ T-cell production in mice. The results reveal a Foxn1-β5t transcriptional axis that governs CD8+ T-cell production in the thymus.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
• 関連情報（DOI）: 10.1038/ncomms14419
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

https://repo.lib.tokushima-u.ac.jp/files/public/11/110920/20171129093811597619/k3099_abstract_review.pdf fulltext

https://repo.lib.tokushima-u.ac.jp/files/public/11/110920/20171129093811910514/k3099_fulltext.pdf fulltext