Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis

• 資料種別: 博士論文
• タイトル: Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis
• 著者・編者: Kawashita, Yoichiro; Morine, Yuji; Ikemoto, Tetsuya; Saito, Yu; Iwahashi, Shuichi; Yamada, Shinichiro; Higashijima, Jun; Imura, Satoru; Ogawa, Hirohisa; Yagi, Toshiyuki; Shimada, Mitsuo
• 著者標目: Kawashita, Yoichiro; Morine, Yuji; Ikemoto, Tetsuya; Saito, Yu; Iwahashi, Shuichi; Yamada, Shinichiro; Higashijima, Jun; Imura, Satoru; Ogawa, Hirohisa; Yagi, Toshiyuki; Shimada, Mitsuo
• 出版事項: Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wily
• 出版年月日等: 2017-08-28
• 出版年（W3CDTF）: 2017-08-28
• 並列タイトル等: Fbxw7発現低下は大腸癌肝転移切除症例の再発予測因子である
• タイトル（掲載誌）: Journal of Hepato-Biliary-Pancreatic Sciences
• 巻号年月日等（掲載誌）: 24 10
• 掲載巻: 24
• 掲載号: 10
• 掲載ページ: 576-583
• ISSN（掲載誌）: ISSN : 1868-6974; ISSN : 1868-6982
• 授与機関名: 徳島大学
• 授与年月日: 2017-11-30
• 報告番号: 甲第3120号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Colorectal liver metastasis; Fbxw7; miR-223; Prognostic factor
• 対象利用者: 一般
• 一般注記: Background/Purpose Fbxw7 is a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of Fbxw7 is frequently observed in various human cancers. In this study, we examined the role of Fbxw7 expression in colorectal liver metastasis (CRLM) and its mechanism. Methods Fifty-six patients with CRLM who undergo curative resection were enrolled. Fbxw7 in tumor tissue was determined by immunohistochemistry. Patients were divided into two groups, the Fbxw7 high and low group. Clinicopathological factors including miR-223 expression were compared between the high (n=32) and low Fbxw7 group (n=24). Results Fbxw7 expression in tumor tissues was significantly lower than that in normal tissues. The disease-free survival in the low Fbxw7 group was significantly worse than that in the high Fbxw7 group, and 3years disease-free survival of the low and the high Fbxw7 group were 12.5% and 47.0%, respectively (p=0.023). On multivariate analysis, loss of Fbxw7 was detected as one of the independent risk factor for recurrence of CRLM (Hazard ratio: 2.390, p=0.017). Likewise, Fbxw7 expression inversely correlated to miR-223 expression (p=0.017). Conclusion Loss of Fbxw7 in tumor tissues could be a reliable predictor of recurrence after hepatectomy in patients with CRLM, and miR223 might be a possible regulator of Fbxw7.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1002/jhbp.500
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/110995/20180109115810190383/k3120_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/110995/20181016175356847922/k3120_fulltext.pdf fulltext