Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors

• 資料種別: 博士論文
• タイトル: Correlation of 3D Arterial Spin Labeling and Multi-Parametric Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors
• 著者・編者: Khashbat, Delgerdalai; Abe, Takashi; Ganbold, Mungunbagana; Iwamoto, Seiji; Uyama, Naoto; Irahara, Saho; Otomi, Youichi; Harada, Masafumi; Kageji, Teruyoshi; Nagahiro, Shinji
• 著者標目: Khashbat, Delgerdalai; Abe, Takashi; Ganbold, Mungunbagana; Iwamoto, Seiji; Uyama, Naoto; Irahara, Saho; Otomi, Youichi; Harada, Masafumi; Kageji, Teruyoshi; Nagahiro, Shinji
• 出版事項: Faculty of Medicine Tokushima University
• 出版年月日等: 2016-08
• 出版年（W3CDTF）: 2016-08
• 並列タイトル等: 脳腫瘍における動脈スピンラベリング法及び多変量ダイナミック磁化率コントラスト灌流MRI法の比較; ASL and DSC MRI of brain tumors
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 63 3-4
• 掲載巻: 63
• 掲載号: 3-4
• 掲載ページ: 175-181
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2016-03-23
• 報告番号: 甲第2956号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: magnetic resonance imaging; arterial spin labeling; dynamic susceptibility contrast perfusion; time to maximum; brain tumor
• 対象利用者: 一般
• 一般注記: Purpose : Arterial spin labeling (ASL) is an alternative method to Dynamic susceptibility contrast (DSC) perfusion MRI for brain tumors. However, ASL cerebral blood flow (CBF) can be easily affected by transit time. DSC MRI derived time to maximum of the residue function (Tmax) is possible to assess the transit time on ASL. Methods : Thirty patients with brain tumors were studied using ASL and DSC MRI. The relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), Tmax, and mean transit time (MTT) were obtained from DSC MRI. The ratios of the parameters were analyzed. Results : ASL CBF ratio correlated with the DSC rCBF ratio (r=0.78, p<0.001) and rCBV ratio (r=0.74, p<0.001). There was a moderate correlation between ASL CBF ratio and Tmax ratio (r=-0.43, p<0.05) in brain tumors. Conclusions : ASL CBF strongly correlated with DSC rCBF and rCBV. In addition, a negative correlation was found between ASL CBF and Tmax in brain tumors, indicating that these parameters would be affected by transit time. This may explain why ASL CBF is different from DSC rCBF and rCBV. The decreased DSC Tmax value may suggest high vascularity in a tumor.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.63.175
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/111177/20190809142059569622/LID201606101003.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/111177/20190809142059888837/LID201609291002.pdf fulltext