Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging

• 資料種別: 博士論文
• タイトル: Default mode network abnormalities in children with autism spectrum disorder detected by resting-state functional magnetic resonance imaging
• 著者・編者: Funakoshi, Yasuhiro; Harada, Masafumi; Otsuka, Hideki; Mori, Kenji; Ito, Hiromichi; Iwanaga, Takashi
• 著者標目: Funakoshi, Yasuhiro; Harada, Masafumi; Otsuka, Hideki; Mori, Kenji; Ito, Hiromichi; Iwanaga, Takashi
• 出版事項: Faculty of Medicine Tokushima University
• 出版年月日等: 2016-08
• 出版年（W3CDTF）: 2016-08
• 並列タイトル等: resting state functional MRIによる自閉性障害若年者におけるdefault mode networkの変化に関する検討; Alteration of default mode network in children with autism spectrum disorder
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 63 3-4
• 掲載巻: 63
• 掲載号: 3-4
• 掲載ページ: 204-208
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2016-12-15
• 報告番号: 甲第3004号
• 学位: 博士（保健学）
• 本文の言語コード: eng
• 件名標目: default mode network; resting state MRI; autism spectrum disorder; interior parietal lobule; posterior cingulate cortex; development
• 対象利用者: 一般
• 一般注記: Purpose : The purpose of this study was to investigate changes in the functional connectivity of the default mode network (DMN) in normal aging and in children with autistic spectrum disorder (ASD) by using resting-state functional magnetic resonance imaging (rsfMRI) and independent component analysis. Methods : Thirty-one healthy controls (HC) in four age groups (1-3, 4-8, 20-29, and 50-59 years) and 14 childhood ASD cases (1-8 years of age) were examined by rsfMRI echo-planar imaging on a clinical 3-T MRI scanner. Imaging of all children (1-8 years) was conducted under sedation, while adults were scanned in the awake state with eyes closed. Results : The regions of DMN functional connectivity in the bilateral inferior parietal lobule and posterior cingulate cortex were smaller in HC children than in HC adults, and smaller in the ASD group than in the HC children. Conclusion : It is possible to observe developmental and pathological changes in the DMN by rsfMRI. Reduced DMN functional connectivity in children may be a useful biomarker for ASD diagnosis.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.63.204
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

https://repo.lib.tokushima-u.ac.jp/files/public/11/111182/20190730161516577311/LID201701261003.pdf fulltext

https://repo.lib.tokushima-u.ac.jp/files/public/11/111182/20190730161517313980/LID201701261004.pdf fulltext

https://repo.lib.tokushima-u.ac.jp/files/public/11/111182/20190730183308169967/LID201701261005.pdf fulltext