A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer

• 資料種別: 博士論文
• タイトル: A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer
• 著者・編者: Daizumoto, Kei; Yoshimaru, Tetsuro; Matsushita, Yosuke; Fukawa, Tomoya; Uehara, Hisanori; Ono, Masaya; Komatsu, Masato; Kanayama, Hiro-omi; Katagiri, Toyomasa
• 著者標目: Daizumoto, Kei; Yoshimaru, Tetsuro; Matsushita, Yosuke; Fukawa, Tomoya; Uehara, Hisanori; Ono, Masaya; Komatsu, Masato; Kanayama, Hiro-omi; Katagiri, Toyomasa
• 出版事項: American Association for Cancer Research
• 出版年月日等: 2018-02-13
• 出版年（W3CDTF）: 2018-02-13
• 並列タイトル等: DDX31/p53変異/EGFR経路は筋層浸潤膀胱癌の多段階進展を促進する; Critical roles of DDX31-mutp53-EGFR axis in MIBC progression
• タイトル（掲載誌）: Cancer Research
• 巻号年月日等（掲載誌）: 78 9
• 掲載巻: 78
• 掲載号: 9
• 掲載ページ: 2233-2247
• ISSN（掲載誌）: ISSN : 0008-5472; ISSN : 1538-7445
• 授与機関名: 徳島大学
• 授与年月日: 2018-04-26
• 報告番号: 甲第3194号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: DDX31; mutant-p53; EGFR; muscle invasive bladder cancer
• 対象利用者: 一般
• 一般注記: The p53 and EGFR pathways are frequently altered in bladder cancers, yet their contributions to its progression remain elusive. Here we report that DEAD box polypeptide 31 (DDX31) plays a critical role in the multistep progression of muscle invasive bladder cancer (MIBC) through its sequential interactions with mutant p53 (mutp53) and EGFR. In early MIBC cells, nuclear DDX31 bound mutp53/SP1 and enhanced mutp53 transcriptional activation, leading to migration and invasion of MIBC. Cytoplasmic DDX31 also bound EGFR and phospho-nucleolin (p-NCL) in advanced MIBC, leading to EGFR-Akt signaling activation. High expression of both cytoplasmic DDX31 and p53 proteins correlated with poor prognosis in patients with MIBC, and blocking the DDX31-NCL interaction resulted in downregulation of EGFR-Akt signaling, eliciting an in vivo anti-tumor effect against bladder cancer. These findings reveal that DDX31 cooperates with mutp53 and EGFR to promote progression of MIBC, and inhibition of DDX31-NCL formation may lead to potential treatment strategies for advanced MIBC.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1158/0008-5472.CAN-17-2528
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/111804/20180614114016926038/k3194_abstract_reveiw.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/111804/20180618143248663704/k3194_fulltext.pdf fulltext