並列タイトル等切迫早産に対する長期入院管理が母児の血中ビタミンD濃度に与える影響
Maternal hospitalization and vitamin D
タイトル（掲載誌）The Journal of Obstetrics and Gynaecology Research
一般注記Aim: We aimed to evaluate the effect of prolonged hospitalization for threatened preterm labor on maternal and fetal vitamin D status.
Methods: This was a retrospective cohort study, spanning 4 years, including 18 women with threatened preterm labor and 36 women with normal pregnancy, who received prenatal care for a singleton pregnancy at our center. Threatened preterm labor cases were women who were admitted to our hospital after the second trimester test, for at least 28 days, during which, the third trimester test was also performed. Controls were randomly sampled from women matched for age as well as the season during which the third trimester test was performed. Serum 25-hydroxyvitamin D concentration in maternal blood was compared between the two groups at second trimester, third trimester and in the umbilical cord blood at delivery.
Results: The mean±SD of maternal serum 25-hydroxyvitamin D concentration in the threatened preterm labor group (14.0±3.0 ng/mL) was significantly lower than that in the control group (17.8±5.9 ng/mL) (p<0.01) in the third trimester, although there was no significant difference in the second trimester (p=0.30). There was a significant reduction (p<0.01) in the maternal serum 25-hydroxyvitamin D from the second to third trimester,in the threatened preterm labor group, compared to the control group (p=0.60). There was no significant difference between the two groups in umbilical cord blood 25-hydroxyvitamin D concentrations at delivery (p=0.41).
Conclusions: Prolonged hospitalization for threatened preterm labor reduced the maternal vitamin D status, but did not influence the neonatal status at delivery.
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）