Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease : New Prediction Model in Combination With Framingham Risk Score

• 資料種別: 博士論文
• タイトル: Local Thickness of Epicardial Adipose Tissue Surrounding the Left Anterior Descending Artery Is a Simple Predictor of Coronary Artery Disease : New Prediction Model in Combination With Framingham Risk Score
• 著者・編者: Gulinu, Maimaituxun; Shimabukuro, Michio; Fukuda, Daiju; Yagi, Shusuke; Hirata, Yukina; Iwase, Takashi; Takao, Shoichiro; Matsuura, Tomomi; Ise, Takayuki; Kusunose, Kenya; Tobiume, Takeshi; Yamaguchi, Koji; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Harada, Masafumi; Sata, Masataka
• 著者標目: Gulinu, Maimaituxun; Shimabukuro, Michio; Fukuda, Daiju; Yagi, Shusuke; Hirata, Yukina; Iwase, Takashi; Takao, Shoichiro; Matsuura, Tomomi; Ise, Takayuki; Kusunose, Kenya; Tobiume, Takeshi; Yamaguchi, Koji; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Harada, Masafumi; Sata, Masataka
• 出版事項: The Japanese Circulation Society
• 出版年月日等: 2018-04-25
• 出版年（W3CDTF）: 2018-04-25
• 並列タイトル等: 左前下行枝冠動脈周囲の局所心外膜脂肪厚は簡便な冠動脈疾患の予測因子である : フラミンガムリスクスコアと組み合わせた新しい予測モデル
• タイトル（掲載誌）: Circulation Journal
• 巻号年月日等（掲載誌）: 82 5
• 掲載巻: 82
• 掲載号: 5
• 掲載ページ: 1369-1378
• ISSN（掲載誌）: ISSN : 1347-4820; ISSN : 1346-9843
• 授与機関名: 徳島大学
• 授与年月日: 2018-09-27
• 報告番号: 甲第3217号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Coronary artery disease; Epicardial adipose tissue; Framingham risk score
• 対象利用者: 一般
• 一般注記: Background: Compared with global cardiac adiposity, the local accumulation of fat surrounding coronary arteries might have a more direct impact on coronary artery disease (CAD). Here, we compared the local epicardial adipose tissue (EAT) thickness and global cardiac adiposity volumes for predicting CAD. Methods and Results: A total of 197 consecutive subjects underwent 320-slice multi-detector computed tomography coronary angiography and were segregated into CAD (≥1 coronary artery branch stenosis ≥50%) and non-CAD groups. EAT thickness was measured at the right coronary artery (EATRCA), the left anterior descending artery (EATLAD), and the left circumflex artery (EATLCX). Although EATRCA and EATLCX were similar between the 2 groups, EATLAD was larger in the CAD group than in the non-CAD group (5.45±2.16 mm vs. 6.86±2.19 mm, P<0.001). EATLAD, after correcting for confounding factors, was strongly associated with CAD (r=0.276, P<0.001) and Gensini score (r=0.239, P<0.001). On multiple regression analysis, Framingham risk score combined with EATLAD was a strong predictor of CAD (adjusted R2=0.121; P<0.001). Conclusions: The local fat thickness surrounding the LAD is a simple and useful surrogate marker for estimating the presence, severity, and extent of CAD, independent of classical cardiovascular risk factors.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1253/circj.CJ-17-1289
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/112879/20181218134709533798/k3217_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/112879/20190325100719935504/k3217_fulltext.pdf fulltext