Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis

• 資料種別: 博士論文
• タイトル: Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis
• 著者・編者: Kasai, Kana; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Keyama, Kaoru; Kawakita, Takako; Yoshida, Kanako; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• 著者標目: Kasai, Kana; Kato, Takeshi; Kadota, Yuri; Erdenebayar, Otgontsetseg; Keyama, Kaoru; Kawakita, Takako; Yoshida, Kanako; Kuwahara, Akira; Matsuzaki, Toshiya; Irahara, Minoru
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2019-02
• 出版年（W3CDTF）: 2019-02
• 並列タイトル等: 子宮内膜症モデルマウスにおいてアクチビンの腹腔内投与は子宮内膜症様病変の増殖を促進する; Activin A promotes endometriotic lesions
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 66 1-2
• 掲載巻: 66
• 掲載号: 1-2
• 掲載ページ: 123-127
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2019-02-06
• 報告番号: 甲第3253号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Endometriosis; Activin A; Mouse model; Inflammatory cytokine
• 対象利用者: 一般
• 一般注記: PURPOSE : This study aimed to investigate the effect of intraperitoneal administration of activin on the occurrence of endometriosis using a mouse model of endometriosis. METHODS : A mouse model of endometriosis was prepared by intraperitoneally administering endometrial tissue and blood collected from donor mice to C57BL/6J 7-8- week-old recipient mice. A total of 400 μg of activin A was intraperitoneally administered to model mice in the activin group for 5 days. Intraperitoneal endometriotic lesions were confirmed macroscopically and IL-6 and TNF-α levels in washed ascites were measured by ELISA. RESULTS : Endometriotic lesions were observed in all mice. In the activin group, the maximum diameter of endometriotic lesions was significantly larger than that in control group (4.7±1.3 vs 2.9±0.9 mm, p<0.01). The total area of the lesion was also significantly higher in the activin group than in the control group (21.1±9.9 vs 8.8±5.4 mm2, p<0.01). Furthermore, IL-6 and TNF-α levels in ascites were significantly higher in the activin group than in the control group (IL-6 : 85.8±15.3 vs 75.1±19.3 pg/ml, p<0.05 ; TNF-α : 629.8±15.4 vs 605.9±11.4 pg/ml, p<0.05). CONCLUSION : Activin promotes occurrence of endometriosis. Inflammatory cytokines are also elevated by activin administration,suggesting that they may contribute to progression of endometriosis
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.66.123
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/113270/20190422151622124981/k3253_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113270/20190724162012224395/k3253_fulltext.pdf fulltext