Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice

• 資料種別: 博士論文
• タイトル: Daily Coffee Intake Inhibits Pancreatic Beta Cell Damage and Nonalcoholic Steatohepatitis in a Mouse Model of Spontaneous Metabolic Syndrome, Tsumura-Suzuki Obese Diabetic Mice
• 著者・編者: Watanabe, Syunsuke; Takahashi, Tetsuyuki; Ogawa, Hirohisa; Uehara, Hisanori; Tsunematsu, Takaaki; Baba, Hayato; Morimoto, Yuki; Tsuneyama, Koichi
• 著者標目: Watanabe, Syunsuke; Takahashi, Tetsuyuki; Ogawa, Hirohisa; Uehara, Hisanori; Tsunematsu, Takaaki; Baba, Hayato; Morimoto, Yuki; Tsuneyama, Koichi
• 出版事項: Mary Ann Liebert, Inc.
• 出版年月日等: 2017-05-01
• 出版年（W3CDTF）: 2017-05-01
• 並列タイトル等: メタボリックシンドロームモデルマウス、TSODマウスにおいて、日常的なコーヒー摂取は膵臓β細胞へのダメージ及び非アルコール性脂肪肝を抑制する; EFFECTS OF COFFEE INTAKE ON METABOLIC SYNDROME
• タイトル（掲載誌）: Metabolic Syndrome and Related Disorders
• 巻号年月日等（掲載誌）: 15 4
• 掲載巻: 15
• 掲載号: 4
• 掲載ページ: 170-177
• ISSN（掲載誌）: ISSN : 1540-4196; ISSN : 1557-8518
• 授与機関名: 徳島大学
• 授与年月日: 2019-03-19
• 報告番号: 甲第3265号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: animal model; beta cell failure; coffee intake; hepatocellular carcinoma; nonalcoholic steatohepatitis
• 対象利用者: 一般
• 一般注記: Background: Metabolic syndrome is one of the most important health issues worldwide. Obesity causes insulin resistance, hyperlipidemia, diabetes, and various diseases throughout the body. The liver phenotype, which is called nonalcoholic steatohepatitis (NASH), frequently progresses to hepatocellular carcinoma. We recently established a new animal model, Tsumura-Suzuki obese diabetic (TSOD) mice, which spontaneously exhibit obesity, diabetes, hyperlipidemia, and NASH with liver nodules. Methods: We examined the effects of coffee intake on various conditions of the metabolic syndrome using TSOD mice. The daily volume of coffee administered was limited so that it reflected the appropriate quantities consumed in humans. To clarify the effects of the specific components, animals were divided into two coffee-intake groups that included with and without caffeine. Results: Coffee intake did not significantly affect obesity and hyperlipidemia in TSOD mice. In contrast, coffee intake caused various degrees of improvement in the pancreatic beta cell damage and steatohepatitis with liver carcinogenesis. Most of the effects were believed to be caused by a synergistic effect of caffeine with other components such as polyphenols. However, the antifibrotic effects of coffee appeared to be due to the polyphenols rather than the caffeine. Conclusions: A daily habit of drinking coffee could possibly play a role in the prevention of metabolic syndrome.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2017, Mary Ann Liebert, Inc.
• 関連情報（DOI）: 10.1089/met.2016.0114
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/113349/20190605153307930543/k3265_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113349/20190605153308502009/k3265_fulltext.pdf fulltext