並列タイトル等高血圧性心疾患における左室拡張期電気機械的カップリングの非侵襲的評価法
Electromechanical Coupling in HHD
タイトル（掲載誌）Journal of Echocardiography
一般注記Background: There is a need to stratify patients who may develop heart failure because of the current “heart failure pandemic”. We hypothesized that noninvasive assessment of diastolic electromechanical coupling by electrocardiography and Doppler echocardiography may be clinically useful for risk stratification of hypertensive patients who may develop heart failure.
Methods: We measured the time from the peak to end of the T-wave (TpTe) as an electrophysiological parameter, and peak early-diastolic mitral flow (E) and lateral annular (e’) velocities as mechanical parameters in 109 patients with hypertension. Relationships between these parameters and their association with the prognosis was evaluated.
Results: The e’ was inversely correlated with TpTe (p<0.001) and QTc (p < 0.014), whereas E/e’ was positively correlated with TpTe (p<0.001) and QTc (p<0.001). The TpTe predicted patients with E/e’ > 12. There were 24 cardiovascular events during follow-up (57 ± 20 months), and Kaplan-Meir analysis showed that outcome was worse (p=0.003) in patients with higher E/e’ than lower E/e’, however, there was no difference between patients with longer TpTe (≧72 msec) and shorter TpTe (<72 msec).
Conclusions: The correlation of TpTe with e’ and E/e’ in hypertensive patients suggests that these parameters reflect diastolic ventricular electromechanical coupling. The E/e’ predicted outcome, and an elevated E/e’ should be suspected when TpTe is prolonged (> 72 msec). Noninvasive evaluation of diastolic electromechanical coupling is clinically useful in patients with hypertension.
関連情報（DOI）10.1007/s12574-019-00421-4
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）