Intracerebroventricular injection of ghrelin decreases wheel running activity in rats

• 資料種別: 博士論文
• タイトル: Intracerebroventricular injection of ghrelin decreases wheel running activity in rats
• 著者・編者: Miyatake, Yumiko; Shiuchi, Tetsuya; Mawatari, Kazuaki; Toda, Satomi; Taniguchi, Yasuko; Futami, Akari; Sato, Fukiko; Kuroda, Masashi; Sebe, Mayu; Tsutsumi, Rie; Harada, Nagakatsu; Minokoshi, Yasuhiko; Kitamura, Tadahiro; Gotoh, Koro; Ueno, Masaki; Nakaya, Yutaka; Sakaue, Hiroshi
• 著者標目: Miyatake, Yumiko; Shiuchi, Tetsuya; Mawatari, Kazuaki; Toda, Satomi; Taniguchi, Yasuko; Futami, Akari; Sato, Fukiko; Kuroda, Masashi; Sebe, Mayu; Tsutsumi, Rie; Harada, Nagakatsu; Minokoshi, Yasuhiko; Kitamura, Tadahiro; Gotoh, Koro; Ueno, Masaki; Nakaya, Yutaka; Sakaue, Hiroshi
• 出版事項: Elsevier Inc.
• 出版年月日等: 2016-11-05
• 出版年（W3CDTF）: 2016-11-05
• 並列タイトル等: グレリンの脳室内投与はラットにおいて回転カゴ運動を減少させる
• タイトル（掲載誌）: Peptides
• 巻号年月日等（掲載誌）: 87
• 掲載巻: 87
• 掲載ページ: 12-19
• ISSN（掲載誌）: ISSN : 0196-9781
• 授与機関名: 徳島大学
• 授与年月日: 2019-03-22
• 報告番号: 甲第3274号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: Ghrelin; Voluntary exercise; Central nervous system; SPORTS rat
• 対象利用者: 一般
• 一般注記: There is an increasing interest in elucidating the molecular mechanisms by which voluntary exercise is regulated. In this study, we examined how the central nervous system regulates exercise. We used SPORTS rats, which were established in our laboratory as a highly voluntary murine exercise model. SPORTS rats showed lower levels of serum ghrelin compared with those of the parental line of Wistar rats. Intrac-erebroventricular and intraperitoneal injection of ghrelin decreased wheel-running activity in SPORTS rats. In addition, daily injection of the ghrelin inhibitor JMV3002 into the lateral ventricles of Wistar rats increased wheel-running activity. Co-administration of obestatin inhibited ghrelin-induced increases in food intake but did not inhibit ghrelin-induced suppression of voluntary exercise in rats. Growth hormone secretagogue receptor (GHSR) in the hypothalamus and hippocampus of SPORTS rats was not difference that in control rats. We created an arcuate nucleus destruction model by administering monosodium glutamate (MSG) to neonatal SPORTS rats. Injection of ghrelin into MSG-treated rats decreased voluntary exercise but did not increase food intake, suggesting that wheel-running activity is not controlled by the arcuate nucleus neurons that regulate feeding. These results provide new insights into the mechanism by which ghrelin regulates voluntary activity independent of arcuate nucleus neurons.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.peptides.2016.11.005
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/113364/20190607111954616432/k3274_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/113364/20190607111955133055/k3274_fulltext.pdf fulltext