Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice

• 資料種別: 博士論文
• タイトル: Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice
• 著者・編者: Yoshimoto, Ayumi; Uebanso, Takashi; Nakahashi, Mutsumi; Shimohata, Takaaki; Mawatari, Kazuaki; Takahashi, Akira
• 著者標目: Yoshimoto, Ayumi; Uebanso, Takashi; Nakahashi, Mutsumi; Shimohata, Takaaki; Mawatari, Kazuaki; Takahashi, Akira
• 出版事項: Society for Free Radical Research Japan
• 出版年月日等: 2018-03-01
• 出版年（W3CDTF）: 2018-03-01
• 並列タイトル等: 胎生期の低用量抗菌薬摂取が、子の腸内細菌叢や体脂肪組成に及ぼす影響
• タイトル（掲載誌）: Journal of Clinical Biochemistry and Nutrition
• 巻号年月日等（掲載誌）: 62 2
• 掲載巻: 62
• 掲載号: 2
• 掲載ページ: 155-160
• ISSN（掲載誌）: ISSN : 0912-0009; ISSN : 1880-5086
• 授与機関名: 徳島大学
• 授与年月日: 2020-03-23
• 報告番号: 甲第3416号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: CE-MS; DGGE; adiposity; maternal; transgenerational
• 対象利用者: 一般
• 一般注記: Several environmental factors during the prenatal period transgenerationally affect the health of newborns in later life. Because low-dose antibiotics have been used for promoting the growth of crops and livestock in agriculture, humans may have ingested residual antibiotics for several decades. However, the effect of prenatal administration of low-dose antibiotics on newborns’ health in later life is unclear. In the present study, we found that prenatal treatment of murine mothers with low-dose antibiotics increased the abundance of bacteria of the phylum Firmicutes and the genera Clostridium IV and XIVa in feces from pups. In addition, the body fat percentage of mice in the antibiotic-treated group was higher than those in the control group at 12 weeks of age even though all pups were fed a standard diet. The body fat percentage of all mice was correlated with the abundance of fecal bacteria of Clostridium IV and XIVa. These results predict that low-dose antibiotic administration during the prenatal period affects the gut microbiota of newborns and possibly their health in later life.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2018 Society for Free Radical Research Japan
• 関連情報（DOI）: 10.3164/jcbn.17-53
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/114647/20200421151012229557/k3416_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114647/20200421151012777609/k3416_fulltext.pdf fulltext