Conditioned media from human dental pulp stem cells prevent radiation-induced skin injury

• 資料種別: 博士論文
• タイトル: Conditioned media from human dental pulp stem cells prevent radiation-induced skin injury
• 著者・編者: Kawarabayashi, Keita; Kano, Fumiya; Hashimoto, Noboru; Hibi, Hideharu; Iwamoto, Tsutomu; Yamamoto, Akihito
• 著者標目: Kawarabayashi, Keita; Kano, Fumiya; Hashimoto, Noboru; Hibi, Hideharu; Iwamoto, Tsutomu; Yamamoto, Akihito
• 出版事項: Shikoku Society of Dental Research
• 出版年月日等: 2020-06-12
• 出版年（W3CDTF）: 2020-06-12
• 並列タイトル等: ヒト歯髄幹細胞由来培養上清による皮膚の放射線障害の抑制効果; Dental pulp stem cell factors for treating RISR
• タイトル（掲載誌）: Journal of Oral Health and Biosciences
• 巻号年月日等（掲載誌）: 33 1
• 掲載巻: 33
• 掲載号: 1
• 掲載ページ: 1-7
• ISSN（掲載誌）: ISSN : 2189-6682
• 授与機関名: 徳島大学
• 授与年月日: 2020-03-23
• 報告番号: 甲第3382号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: human dental pulp stem cells; conditioned media; mesenchymal stem cells; radiation-induced skin reaction; cutaneous radiation syndrome; radiation-induced skin reactions
• 対象利用者: 一般
• 一般注記: Radiation-induced skin ulceration is a frequent complication of radiotherapy for cancer treatment. Stem cells from human exfoliated deciduous teeth (SHEDs) can regenerate various tissues. In this study, we investigated the impact of SHED-conditioned media (SHED-CM) on radiation-induced ulceration. Mouse necks were locally irradiated with a single dose of 15 Gy of radiation. A week after the irradiation, most of the wild-type mice generated ulcer surrounded by severe erythema. Intra-venous administration of SHED-CM effectively inhibited the ulcer formation. Histological examination revealed that SHED-CM treatment inhibited radiation-induced dermal thickness and epithelial hyperplasia. SHED-CM could be a useful treatment option for radiation-induced skin ulceration.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.20738/johb.33.1_1
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/114712/20200616141705848696/johb_33_1_1.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114712/20200616141706713779/k3382_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114712/20200616141707321831/k3382_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/114712/20200616141707672029/k3382_fulltext.pdf fulltext