Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease

• 資料種別: 博士論文
• タイトル: Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease
• 著者・編者: Niida, Yuki; Masuda, Masashi; Adachi, Yuichiro; Yoshizawa, Aika; Ohminami, Hirokazu; Mori, Yuki; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Uchida, Takayuki; Nikawa, Takeshi; Yamamoto, Hironori; Miyazaki, Makoto; Taketani, Yutaka
• 著者標目: Niida, Yuki; Masuda, Masashi; Adachi, Yuichiro; Yoshizawa, Aika; Ohminami, Hirokazu; Mori, Yuki; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Uchida, Takayuki; Nikawa, Takeshi; Yamamoto, Hironori; Miyazaki, Makoto; Taketani, Yutaka
• 出版事項: Society for Free Radical Research Japan
• 出版年月日等: 2020-09-01
• 出版年（W3CDTF）: 2020-09-01
• 並列タイトル等: stearoyl-CoA desaturaseの低下は慢性腎臓病における過剰な小胞体ストレスを介して筋萎縮に寄与する
• タイトル（掲載誌）: Journal of Clinical Biochemistry and Nutrition
• 巻号年月日等（掲載誌）: 67 2
• 掲載巻: 67
• 掲載号: 2
• 掲載ページ: 179-187
• ISSN（掲載誌）: ISSN : 0912-0009; ISSN : 1880-5086
• 授与機関名: 徳島大学
• 授与年月日: 2020-03-23
• 報告番号: 甲第3419号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: skeletal muscle atrophy; endoplasmic reticulum (ER) stress; chronic kidney disease (CKD); stearoyl-CoA desaturase (SCD); saturated fatty acid (SFA)
• 対象利用者: 一般
• 一般注記: Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. The quality of lipids (lipoquality), which is defined as the functional features of diverse lipid species, has recently been recognized as the pathology of various diseases. In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. In comparison to control rats, CKD rats decreased the SCD activity and its gene expression in atrophic gastrocnemius muscle. Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. These results suggest that the repression of SCD activity causes muscle atrophy through excessive endoplasmic reticulum stress in CKD.
• 記録形式（IMT）: application/pdf
• 一次資料へのリンクURL: fulltext; http://repo.lib.tokushima-u.ac.jp/files/public/11/114720/2020050815222832544/k3419_abstract_review.pdf; http://repo.lib.tokushima-u.ac.jp/files/public/11/114720/20200903120200240321/k3419_fulltext.pdf
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: © 2020 Society for Free Radical Research Japan
• 関連情報（DOI）: 10.3164/jcbn.20-24
• 掲載誌（NCID）: AA10710201; https://ci.nii.ac.jp/ncid/AA10710201
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ