並列タイトル等性別に基づく血清葉酸濃度と統合失調症との関連
Folate and sex in schizophrenia
Association between serum folate levels and schizophrenia based on gender
Folate and gender in schizophrenia
タイトル（掲載誌）Psychiatry and Clinical Neurosciences
一般注記Aim: Gender differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on gender. In this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non‐psychiatric controls stratified by gender. The relationships between serum folate levels, plasma total homocysteine (tHcy) and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies.
Methods: The serum folate concentrations of 482 patients diagnosed with schizophrenia and 1,350 non‐psychiatric control subjects were measured. We conducted an analysis of covariance to examine the differences in serum folate levels between the two groups based on gender. Spearman’s rank correlation was used to evaluate the relationships between folate, tHcy and vitamin B6 levels.
Results: In the control group, serum folate concentrations were higher in women than in men. Lower levels of serum folate were observed in both male and female patients with schizophrenia. An inverse correlation between serum folate and plasma tHcy and a weak positive correlation between serum folate and vitamin B6 were observed in the combined cohort.
Conclusion: Our findings suggest that (1) a low serum folate level may be associated with schizophrenia regardless of gender, and (2) folate administration may be beneficial for the treatment of schizophrenia. In schizophrenic patients with low serum folate levels, folate administration might result in improvements in high tHcy and an increase in low vitamin B6 levels.
著作権情報This is the peer reviewed version of the following article: Tomioka, Y., Kinoshita, M., Umehara, H., Nakayama, T., Watanabe, S.‐y., Nakataki, M., Numata, S. and Ohmori, T. (2020), Association between serum folate levels and schizophrenia based on sex. Psychiatry Clin. Neurosci., 74: 466-471, which has been published in final form at https://doi.org/10.1111/pcn.13074.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）