Vibrio parahaemolyticus induces inflammation-associated fluid accumulation via activation of the cystic fibrosis transmembrane conductance regulator

• 資料種別: 博士論文
• タイトル: Vibrio parahaemolyticus induces inflammation-associated fluid accumulation via activation of the cystic fibrosis transmembrane conductance regulator
• 著者・編者: Iba, Hitomi; Shimohata, Takaaki; Kido, Junko; Hatayama, Sho; Uebanso, Takashi; Mawatari, Kazuaki; Takahashi, Akira
• 著者標目: Iba, Hitomi; Shimohata, Takaaki; Kido, Junko; Hatayama, Sho; Uebanso, Takashi; Mawatari, Kazuaki; Takahashi, Akira
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2021-02
• 出版年（W3CDTF）: 2021-02
• 並列タイトル等: 腸炎ビブリオは炎症を誘導し、Cystic Fibrosis Transmembrane Conductance Regulatorを介して下痢を誘導する; CFTR associated diarrhea in VP-infection
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 68 1-2
• 掲載巻: 68
• 掲載号: 1-2
• 掲載ページ: 59-70
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2021-01-28
• 報告番号: 甲第3471号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: Vibrio parahaemolyticus; CFTR; inflammation; diarrhea; COX-2
• 対象利用者: 一般
• 一般注記: Vibrio parahaemolyticus is a foodborne bacterium that causes acute gastroenteritis through the consumption of contaminated, raw, or undercooked seafood. Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel that regulates several other ion channels and transporters to maintain water homeostasis in the gut lumen. Also, CFTR is a main target of bacterial infection-associated diarrhea. Hence, the aim of this study was to clarify the contribution of CFTR in V. parahaemolyticus-induced diarrhea in a mouse model of intestinal loop fluid accumulation, with CFTR inhibitors and a CFTR knockout model. The results indicated that CFTR plays a critical role in fluid accumulation in response to V. parahaemolyticus infection. We also investigated the inflammatory association in CFTR-mediated V. parahaemolyticus-induced fluid secretion with cyclooxygenase inhibitors and found that fluid accumulation was decreased by inhibition of cyclooxygenase 2 produced by neutrophils. These findings suggest that V. parahaemolyticus-inducing infiltration and activation of neutrophils also participated in CFTR mediated fluid secretion. This study reveals an important relationship between V. parahaemolyticus-induced diarrhea and inflammation in a mouse model.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.68.59
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/115628/20210202160904982916/k3471_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/115628/20210519101540916288/k3471_fulltext.pdf fulltext