Vestibular and cochlear nerve enhancement on MRI and its correlation with vestibulocochlear functional deficits in patients with Ramsay Hunt syndrome

• 資料種別: 博士論文
• タイトル: Vestibular and cochlear nerve enhancement on MRI and its correlation with vestibulocochlear functional deficits in patients with Ramsay Hunt syndrome
• 著者・編者: Takahashi, Mika; Sato, Go; Toda, Naoki; Azuma, Takahiro; Nakamura, Katsuhiko; Iwasaki, Hidetaka; Miyoshi, Hitomi; Matsuda, Kazunori; Kitamura, Yoshiaki; Abe, Koji; Takao, Shoichiro; Harada, Masafumi; Takeda, Noriaki
• 著者標目: Takahashi, Mika; Sato, Go; Toda, Naoki; Azuma, Takahiro; Nakamura, Katsuhiko; Iwasaki, Hidetaka; Miyoshi, Hitomi; Matsuda, Kazunori; Kitamura, Yoshiaki; Abe, Koji; Takao, Shoichiro; Harada, Masafumi; Takeda, Noriaki
• 出版事項: Oto-Rhino-Laryngological Society of Japan|Elsevier
• 出版年月日等: 2020-09-11
• 出版年（W3CDTF）: 2020-09-11
• 並列タイトル等: ラムゼイ・ハント症候群症例の前庭蝸牛神経MRI造影効果と前庭蝸牛機能障害との関係
• タイトル（掲載誌）: Auris Nasus Larynx
• 巻号年月日等（掲載誌）: 48 3
• 掲載巻: 48
• 掲載号: 3
• 掲載ページ: 347-352
• ISSN（掲載誌）: ISSN : 0385-8146
• 授与機関名: 徳島大学
• 授与年月日: 2021-02-25
• 報告番号: 甲第3479号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Ramsay Hunt syndrome; Varicella-zoster virus; Vestibular nerve; Cochlear nerve; Gd-enhanced MRI
• 対象利用者: 一般
• 一般注記: Objective: The correlation between enhancement of the vestibulocochlear nerves on gadolinium-enhanced magnetic resonance imaging (MRI) and vestibulocochlear functional deficits was examined in patients with Ramsay Hunt syndrome (RHS). Methods: Nineteen patients with RHS who showed herpes zoster oticus, peripheral facial palsy, and vertigo were enrolled. Canal paresis (CP) in the caloric test, abnormal response to ocular and cervical vestibular myogenic potentials (oVEMP and cVEMP), and refractory sensorineural hearing loss were evaluated. MRI images perpendicular to the internal auditory canal were reconstructed to identify the superior (SVN) and inferior vestibular nerves (IVN) and the cochlear nerve (CV). The signal intensity increase (SIinc) of the four-nerve enhancement was calculated as an index. Results: Among RHS patients, 79%, 53%, 17% and 26% showed CP in the caloric test, abnormal responses to oVEMP and cVEMP, and refractory sensorineural hearing loss, respectively. SIinc rates of the SVN were significantly increased in RHS patients with CP in the caloric test, and with abnormal responses to oVEMP and cVEMP. SIinc rates of the SVN tended to increase in RHS patients with refractory sensorineural hearing loss ( p = 0.052). SIinc rates of the IVN were significantly increased in RHS patients with abnormal responses to oVEMP and cVEMP, and refractory sensorineural hearing loss, but not in those with CP in the caloric test. SIinc rates of the CN were significantly increased in RHS patients with CP in the caloric test, abnormal response to oVEMP and refractory sensorineural hearing loss, but not in those with abnormal response to cVEMP. Conclusion: In patients with RHS, the origin of vertigo may be superior vestibular neuritis, which is affected by reactive varicella-zoster virus from the geniculate ganglion of the facial nerve through the faciovestibular anastomosis. The results also suggested that in some RHS patients, inferior vestibular neuritis contributes to the development of vertigo and that the origin of refractory sensorineural hearing loss is cochlear neuritis.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.anl.2020.08.027
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/115938/20210507133803389045/k3479_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/115938/20210507133803930485/k3479_fulltext.pdf fulltext