Dendritic Cells Directly Recognize Nickel Ions as an Antigen during the Development of Nickel Allergy

• 資料種別: 博士論文
• タイトル: Dendritic Cells Directly Recognize Nickel Ions as an Antigen during the Development of Nickel Allergy
• 著者・編者: Liu, Lipei; Watanabe, Megumi; Minami, Norikazu; Yunizar, Mohammad Fadyl; Ichikawa, Tetsuo
• 著者標目: Liu, Lipei; Watanabe, Megumi; Minami, Norikazu; Yunizar, Mohammad Fadyl; Ichikawa, Tetsuo
• 出版事項: 四国歯学会
• 出版年月日等: 2022-03-06
• 出版年（W3CDTF）: 2022-03-06
• 並列タイトル等: 樹状細胞はニッケルアレルギーの発症時にニッケルイオンを抗原として直接認識する
• タイトル（掲載誌）: Journal of Oral Health and Biosciences
• 巻号年月日等（掲載誌）: 34 2
• 掲載巻: 34
• 掲載号: 2
• 掲載ページ: 40-52
• ISSN（掲載誌）: ISSN : 2189-6682
• 授与機関名: 徳島大学
• 授与年月日: 2022-03-10
• 報告番号: 甲第3586号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Metal allergy; Nickel ions; Phagocytosis; Dendritic cell migration
• 対象利用者: 一般
• 一般注記: Metal hypersensitivity, a disorder of the immune system, typically manifests as contact hypersensitivity to metals during daily contact. The molecular mechanism whereby metals enter the body and cause allergic disorders remains elusive. It is thought that eluted metal ions are captured by dendritic cells (DCs) and transferred to the draining lymph nodes to activate T cells. Here, for the first time, we used a metal indicator Newport Green to locate the most common allergenic metal, nickel (Ni) ions, captured by DCs and transferred to lymph nodes. Capturing Ni ions did not affect the activity of DCs. Ni ions entered DCs and showed positive staining in keratinocytes. A time varied quantitative analysis demonstrated that at 1 h, a small amount of Ni ions was observed in the epidermal sheet. After 6 h, the number of Ni ions that entered the epidermal sheet reached a peak and remained constant for a few days and were gradually emitted 48 h later. In the cervical lymph nodes of mice, accumulation of Ni ions reached a peak within 24 h and then gradually decreased. The findings of this study will contribute to the development of effective diagnoses and treatment methods for patients allergic to Ni.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.20738/johb.34.2_40
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/116784/2022042613135744531/k3586_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116784/20220426131357123469/k3586_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116784/20220426131357273750/k3586_fulltext.pdf fulltext