CELL TYPE-SPECIFIC LOCALIZATION OF OPTINEURIN IN THE STRIATAL NEURONS OF MICE : IMPLICATIONS FOR NEURONAL VULNERABILITY IN HUNTINGTON'S DISEASE

• 資料種別: 博士論文
• タイトル: CELL TYPE-SPECIFIC LOCALIZATION OF OPTINEURIN IN THE STRIATAL NEURONS OF MICE : IMPLICATIONS FOR NEURONAL VULNERABILITY IN HUNTINGTON'S DISEASE
• 著者・編者: Okita, Shinya; Morigaki, Ryoma; Koizumi, H.; Kaji, Ryuji; Nagahiro, Shinji; Goto, Satoshi
• 著者標目: Okita, Shinya; Morigaki, Ryoma; Koizumi, H.; Kaji, Ryuji; Nagahiro, Shinji; Goto, Satoshi
• 出版事項: Elsevier|International Brain Research Organization
• 出版年月日等: 2011-12-03
• 出版年（W3CDTF）: 2011-12-03
• 並列タイトル等: マウス線条体ニューロンにおけるオプチニューリンの細胞特異的局在 : ハンチントン病における神経脆弱性への影響
• タイトル（掲載誌）: Neuroscience
• 巻号年月日等（掲載誌）: 202
• 掲載巻: 202
• 掲載ページ: 363-370
• ISSN（掲載誌）: ISSN : 0306-4522
• 授与機関名: 徳島大学
• 授与年月日: 2022-03-16
• 報告番号: 甲第3587号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Huntington's disease; optineurin; Huntingtin; medium spiny neuron; Tyramide Signal Amplification; striatum; interneurons; neurodegeneration
• 対象利用者: 一般
• 一般注記: Striatal neuropathology of Huntington's disease (HD) involves primary and progressive degeneration of the medium-sized projection neurons, with relative sparing of the local circuit interneurons. The mechanism for such a patterned cell loss in the HD striatum continues to remain unclear. Optineurin (OPTN) is one of the proteins interacting with huntingtin and plays a protective role in several neurodegenerative disorders. To determine the cellular localization pattern of OPTN in the mouse striatum, we employed a highly sensitive immunohistochemistry with the tyramide signal amplification system. In this study, we show that OPTN appeared as a cytoplasmic protein within the subsets of the striatal neurons. Of particular interest was that OPTN was abundantly expressed in the interneurons, whereas low levels of OPTN were observed in the medium projection neurons. This cell type-specific distribution of OPTN in the striatum is strikingly complementary to the pattern of neuronal loss typically observed in the striatum of patients with HD. We suggest that OPTN abundance is an important cellular factor in considering the cell type-specific vulnerability of striatal neurons in HD.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.neuroscience.2011.11.059
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/116978/20220428141515213390/k3587_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116978/20220428141515515645/k3587_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/116978/20220428141515848402/k3587_fulltext.pdf fulltext