Dietary polyphosphate has a greater effect on renal damage and FGF23 secretion than dietary monophosphate

• 資料種別: 博士論文
• タイトル: Dietary polyphosphate has a greater effect on renal damage and FGF23 secretion than dietary monophosphate
• 著者・編者: Sasaki, Sumire; Koike, Megumi; Tanifuji, Kazuya; Uga, Minori; Kawahara, Kota; Komiya, Aoi; Miura, Mizuki; Harada, Yamato; Hamaguchi, Yuki; Sasaki, Shohei; Shiozaki, Yuji; Kaneko, Ichiro; Miyamoto, Ken-ichi; Segawa, Hiroko
• 著者標目: Sasaki, Sumire; Koike, Megumi; Tanifuji, Kazuya; Uga, Minori; Kawahara, Kota; Komiya, Aoi; Miura, Mizuki; Harada, Yamato; Hamaguchi, Yuki; Sasaki, Shohei; Shiozaki, Yuji; Kaneko, Ichiro; Miyamoto, Ken-ichi; Segawa, Hiroko
• 出版事項: Tokushima University Faculty of Medicine
• 出版年月日等: 2022-08
• 出版年（W3CDTF）: 2022-08
• 並列タイトル等: 食餌性ポリリン酸は、モノリン酸よりも腎障害およびFGF23分泌に大きな影響を与える; In vivo response of dietary polyphosphate
• タイトル（掲載誌）: The Journal of Medical Investigation
• 巻号年月日等（掲載誌）: 69 3-4
• 掲載巻: 69
• 掲載号: 3-4
• 掲載ページ: 173-179
• ISSN（掲載誌）: ISSN : 1349-6867; ISSN : 1343-1420
• 授与機関名: 徳島大学
• 授与年月日: 2022-03-30
• 報告番号: 甲第3637号
• 学位: 博士（栄養学）
• 本文の言語コード: eng
• 件名標目: Polyphosphate; FGF23; Kidney; Intestine; Diet
• 対象利用者: 一般
• 一般注記: Phosphate (Pi)-containing food additives are used in several forms. Polyphosphate (PPi) salt has more harmful effects than monophosphate (MPi) salt on bone physiology and renal function. This study aimed to analyze the levels of parathyroid hormone PTH and fibroblast growth factor 23 (FGF23) and the expression of renal / intestinal Pi transport-related molecules in mice fed with an MPi or PPi diet. There were no significant differences in plasma Pi concentration and fecal Pi excretion levels between mice fed with the high-MPi and PPi diet. However, more severe tubular dilatation, interstitial fibrosis, and calcification were observed in the kidneys of mice fed with the high PPi diet versus the MPi diet. Furthermore, there was a significant increase in serum FGF23 levels and a decrease in renal phosphate transporter protein expression in mice fed with the PPi diet versus the MPi diet. Furthermore, the high MPi diet was associated with significantly suppressed expression and activity of intestinal alkaline phosphatase protein. In summary, PPi has a more severe effect on renal damage than MPi, as well as induces more FGF23 secretion. Excess FGF23 may be more involved in inflammation, fibrosis, and calcification in the kidney.
• 記録形式（IMT）: application/pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2152/jmi.69.173
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/117148/20220602120403836240/k3637_abstract_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/117148/20221018160010194428/k3637_fulltext.pdf fulltext