Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis

• 資料種別: 博士論文
• タイトル: Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis
• 著者・編者: Raman, Swarna Lakshmi; Waskitho, Arief; Raju, Resmi; Iwasa, Takuma; Ikutame, Daisuke; Okura, Kazuo; Oshima, Masamitsu; Matsuka, Yoshizo
• 著者標目: Raman, Swarna Lakshmi; Waskitho, Arief; Raju, Resmi; Iwasa, Takuma; Ikutame, Daisuke; Okura, Kazuo; Oshima, Masamitsu; Matsuka, Yoshizo
• 出版事項: MDPI
• 出版年月日等: 2022-05-24
• 出版年（W3CDTF）: 2022-05-24
• 並列タイトル等: 神経障害性疼痛モデル動物におけるトラニラストの鎮痛効果とテトラヒドロビオプテリン合成制御の役割
• タイトル（掲載誌）: International Journal of Molecular Sciences
• 巻号年月日等（掲載誌）: 23 11
• 掲載巻: 23
• 掲載号: 11
• 掲載ページ: 5878-
• ISSN（掲載誌）: ISSN : 1422-0067
• 授与機関名: 徳島大学
• 授与年月日: 2023-09-20
• 報告番号: 甲第3750号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: orofacial pain; neuropathic pain; infraorbital nerve constriction; nerve injury; tetrahydrobiopterin; tranilast; trigeminal ganglion
• 対象利用者: 一般
• 一般注記: Trigeminal neuralgia is unilateral, lancinating, episodic pain that can be provoked by routine activities. Anticonvulsants, such as carbamazepine, are the drugs of choice; however, these possess side-effects. Microvascular decompression is the most effective surgical technique with a higher success rate, although occasionally causes adverse effects. The potential treatment for this type of pain remains unmet. Increased tetrahydrobiopterin (BH4) levels have been reported in association with axonal injury. This study aimed to evaluate the effect of tranilast on relieving neuropathic pain in animal models and analyze the changes in BH4 synthesis. Neuropathic pain was induced via infraorbital nerve constriction. Tranilast, carbamazepine, or saline was injected intraperitoneally to assess the rat’s post-intervention pain response. In the von Frey’s test, the tranilast and carbamazepine groups showed significant changes in the head withdrawal threshold in the ipsilateral whisker pad area. The motor coordination test showed no changes in the tranilast group, whereas the carbamazepine group showed decreased performance, indicating impaired motor coordination. Trigeminal ganglion tissues were used for the PCR array analysis of genes that regulate the BH4 pathway. Downregulation of the sepiapterin reductase (Spr) and aldoketo reductase (Akr) genes after tranilast injection was observed compared to the pain model. These findings suggest that tranilast effectively treats neuropathic pain.
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
• 関連情報（DOI）: 10.3390/ijms23115878
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/118650/20231018145611602343/k3750_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118650/20231018145611701398/k3750_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118650/20231018145611795224/k3750_fulltext.pdf fulltext