Concomitant Use of Multiple Nephrotoxins Including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity : Combined Retrospective Analyses of Two Real-World Databases

• 資料種別: 博士論文
• タイトル: Concomitant Use of Multiple Nephrotoxins Including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity : Combined Retrospective Analyses of Two Real-World Databases
• 著者・編者: Bando, Takashi; Chuma, Masayuki; Hamano, Hirofumi; Niimura, Takahiro; Okada, Naoto; Kondo, Masateru; Izumi, Yuki; Ishida, Shunsuke; Yoshioka, Toshihiko; Asada, Mizuho; Zamami, Yoshito; Takechi, Kenshi; Goda, Mitsuhiro; Miyata, Koji; Yagi, Kenta; Izawa-Ishizawa, Yuki; Azuma, Momoyo; Yanagawa, Hiroaki; Tasaki, Yoshikazu; Ishizawa, Keisuke
• 著者標目: Bando, Takashi; Chuma, Masayuki; Hamano, Hirofumi; Niimura, Takahiro; Okada, Naoto; Kondo, Masateru; Izumi, Yuki; Ishida, Shunsuke; Yoshioka, Toshihiko; Asada, Mizuho; Zamami, Yoshito; Takechi, Kenshi; Goda, Mitsuhiro; Miyata, Koji; Yagi, Kenta; Izawa-Ishizawa, Yuki; Azuma, Momoyo; Yanagawa, Hiroaki; Tasaki, Yoshikazu; Ishizawa, Keisuke
• 出版事項: Okayama University Medical School
• 出版年月日等: 2023-12
• 出版年（W3CDTF）: 2023-12
• 並列タイトル等: 腎血流量を低下させる薬剤を含む複数の腎毒性を有する薬の併用はバンコマイシン関連腎障害を引き起こす : 2つのリアルワールドデータベースを組み合わせた後方視的研究; Nephrotoxicity with VCM and Nephrotoxins
• タイトル（掲載誌）: Acta Medica Okayama
• 巻号年月日等（掲載誌）: 77 6
• 掲載巻: 77
• 掲載号: 6
• 掲載ページ: 595-605
• ISSN（掲載誌）: ISSN : 0386-300X
• 授与機関名: 徳島大学
• 授与年月日: 2023-10-26
• 報告番号: 甲第3761号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: vancomycin-associated nephrotoxicity; polypharmacy; nephrotoxin; spontaneous adverse event reporting database; electronic medical records
• 対象利用者: 一般
• 一般注記: There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51–1.85]; VCM + ≥ 2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37–1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42–2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: CopyrightⒸ 2023 by Okayama University Medical School
• 関連情報（DOI）: 10.18926/AMO/66151
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/118742/20240112150258894475/k3761_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118742/20240112150258982831/k3761_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/118742/20240112150259234295/k3761_fulltext.pdf fulltext