Defective endoplasmic reticulum stress response via X box-binding protein 1 is a major cause of poor liver regeneration after partial hepatectomy in mice with non-alcoholic steatohepatitis

• 資料種別: 博士論文
• タイトル: Defective endoplasmic reticulum stress response via X box-binding protein 1 is a major cause of poor liver regeneration after partial hepatectomy in mice with non-alcoholic steatohepatitis
• 著者・編者: Miyazaki, Katsuki; Saito, Yu; Ichimura-Shimizu, Mayuko; Imura, Satoru; Ikemoto, Tetsuya; Yamada, Shinichiro; Tokuda, Kazunori; Morine, Yuji; Tsuneyama, Koichi; Shimada, Mitsuo
• 著者標目: Miyazaki, Katsuki; Saito, Yu; Ichimura-Shimizu, Mayuko; Imura, Satoru; Ikemoto, Tetsuya; Yamada, Shinichiro; Tokuda, Kazunori; Morine, Yuji; Tsuneyama, Koichi; Shimada, Mitsuo
• 出版事項: Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wiley
• 出版年月日等: 2022-03-24
• 出版年（W3CDTF）: 2022-03-24
• 並列タイトル等: X box-binding protein１を介した小胞体ストレス応答不全は非アルコール性脂肪肝炎モデルマウスにおける肝部分切除後の肝再生不良の主要な要因である
• タイトル（掲載誌）: Journal of Hepato-Biliary-Pancreatic Sciences
• 巻号年月日等（掲載誌）: 29 12
• 掲載巻: 29
• 掲載号: 12
• 掲載ページ: 1241-1252
• ISSN（掲載誌）: ISSN : 1868-6974; ISSN : 1868-6982
• 授与機関名: 徳島大学
• 授与年月日: 2024-03-21
• 報告番号: 甲第3791号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: Nonalcoholic steatohepatitis; hepatectomy; liver regeneration; endoplasmic reticulum stress response; lipid droplets
• 対象利用者: 一般
• 一般注記: Background Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Poor regeneration after hepatectomy in NAFLD is well recognized, but the mechanism is unclear. Endoplasmic reticulum (ER) stress plays an important role in the development of NAFLD. Here, we show that an impaired ER stress response contributes to poor liver regeneration in partially hepatectomized mice. Methods Non-alcoholic fatty liver (NAFL) or non-alcoholic steatohepatitis (NASH) was induced in mice using our patented feed and 70% partial hepatectomy (PH) was performed. Mice were sacrificed 0, 4, 8, 24, or 48 hours, or 7 days after PH, and liver regeneration and the mRNA expression of ER stress markers were assessed. Results NAFLD activity score was calculated as 4–6 points for NAFL and 7 points for NASH. NASH was characterized by inflammation and high ER stress marker expression before PH. After PH, NASH mice showed poorer liver regeneration than controls. High expression of proinflammatory cytokine genes was present in NASH mice 4 hours after PH. Xbp1-s mRNA expression was high in control and NAFL mice after PH, but no higher in NASH mice. Conclusions Dysfunction of the ER stress response might be a cause of poor liver regeneration in NASH.
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1002/jhbp.1142
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 徳島大学 : 徳島大学機関リポジトリ

目次

http://repo.lib.tokushima-u.ac.jp/files/public/11/119324/20240501143813386265/k3791_abstract.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119324/20240509143858730034/k3791_review.pdf fulltext

http://repo.lib.tokushima-u.ac.jp/files/public/11/119324/2024050914385960797/k3791_fulltext.pdf fulltext