Effects on Circulating VEGF Concentration on Periodontal Surgery in Diabetic Rats

• 資料種別: 博士論文
• タイトル: Effects on Circulating VEGF Concentration on Periodontal Surgery in Diabetic Rats
• 著者・編者: 森⽥, 浩正
• 著者標目: 森⽥, 浩正
• 出版事項: Japanese Association of Regenerative Dentistry
• 並列タイトル等: 糖尿病ラットに⾏った⻭周外科的侵襲による循環⾎中 VEGF 濃度に対する影響
• 授与機関名: 大阪歯科大学
• 授与年月日: 2015-03-06
• 報告番号: 甲第749号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: circulating VEGF concentration; periodontal surgery; diabetes mellitus
• 対象利用者: 一般
• 一般注記: Vascular endothelial growth factor (VEGF) has been recognized as closely related diabetic complications. In this study, we created periodontal defects in diabetic model rats and examined the effects of VEGF expressed in wound healing process on the circulating VEGF concentration.In type 2 diabetic model (GK) and normal (SD) rats, periodontal defects were prepared in the bilateral upper molar regions. The VEGF expression in the periodontium 3, 5, and 7 days after surgery was examined by immunohistochemical staining. In addition, circulating blood was collected from the right atrium, and the plasma VEGF concentration was determined by ELISA.VEGF was expressed more intensely around microvessels, and the plasma VEGF concentration was higher in GK rats than in the SD rats throughout the study.These results suggest that, after periodontal surgery in diabetic rats, VEGF expressed in the periodontium affects the circulating VEGF concentration.; 2014年度
• 一次資料へのリンクURL: fulltext; https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=87&item_no=1&attribute_id=20&file_no=1; https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=87&item_no=1&attribute_id=20&file_no=2
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 大阪歯科大学 : 大阪歯科大学学術リポジトリ