Porous Alpha-Tricalcium Phosphate with Immobilized Basic Fibroblast Growth Factor Enhances Bone Regeneration in a Canine Mandibular Bone Defect Model

• 資料種別: 博士論文
• タイトル: Porous Alpha-Tricalcium Phosphate with Immobilized Basic Fibroblast Growth Factor Enhances Bone Regeneration in a Canine Mandibular Bone Defect Model
• 著者・編者: 小林, 信博
• 著者標目: 小林, 信博
• 並列タイトル等: イヌ下顎骨骨欠損モデルにおいて塩基性線維芽細胞増殖因子を固定させたα-リン酸三カルシウム多孔質体は骨再生を促進させる
• 授与機関名: 大阪歯科大学
• 授与年月日: 2017-03-10
• 報告番号: 甲第798号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: alpha-tricalcium phosphate ｜basic fibroblast growth factor ｜ bone regeneration
• 対象利用者: 一般
• 一般注記: The effect of porous alpha-tricalcium phosphate (-TCP) with immobilized basic fibroblast growth factor (bFGF) on bone regeneration was evaluated in a canine mandibular bone defect model. Identical bone defects were made in the canine mandible; six defects in each animal were filled with porous α-TCP with bFGF bound via heparin (bFGF group), whereas the other was filled with unmodified porous α-TCP (control group). Micro-computed tomography and histological evaluation were performed 2, 4, and 8 weeks after implantation. The bone mineral density of the bFGF group was higher than that of the control group at each time point (P < 0.05), and the bone mineral content of the bFGF group was higher than that of the control group at 4 and 8 weeks (P < 0.05). Histological evaluation 2 weeks after implantation revealed that the porous -TCP had degraded and bone had formed on the surface of -TCP particles in the bFGF group. At 8 weeks, continuous cortical bone with a Haversian structure covered the top of bone defects in the bFGF group. These findings demonstrate that porous -TCP with immobilized bFGF can promote bone regeneration.; 2016年度
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: CC BY-NC-ND
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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