Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland

• 資料種別: 博士論文
• タイトル: Expression of Grhl2 and Its Target Gene Products in Developing Mouse Submandibular Gland
• 著者・編者: 松下, 巧
• 著者標目: 松下, 巧
• 並列タイトル等: マウス顎下腺発生過程における転写因子 Grhl2 とその標的遺伝子の発現
• 授与機関名: 大阪歯科大学
• 授与年月日: 2017-03-10
• 報告番号: 甲第807号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Grhl2; SPINT1; Matriptase; Salivary gland; Development
• 対象利用者: 一般
• 一般注記: Development of the salivary gland is characterized by extensive branching morphogenesis and lumen formation as well as differentiation into acinar and ductal cells. Although various molecules have been implicated in salivary gland development, transcription factors regulating the expression of those molecules and salivary gland development are largely unknown. The GRHL2 transcription factor and its target gene product SPINT1 as well as the SPINT1-regualted protease matriptase play crucial roles in epithelial development in several organs. Here we examined the expression of these epithelial regulators in developing mouse SMG. Of the three Grhl gene members, Grhl2 was the most abundant in embryonic SMG. The expression levels of GRHL2, SPINT1 and matriptase were increased during development of the gland. All of these molecules were expressed exclusively in the epithelial tissue. The present data may suggest the involvement of these molecules in SMG development and give a clue to developing a regenerative therapy of damaged salivary glands.; 2016年度
• 一次資料へのリンクURL: fulltext; https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=165&item_no=1&attribute_id=20&file_no=2; https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=165&item_no=1&attribute_id=20&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 大阪歯科大学 : 大阪歯科大学学術リポジトリ