Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Experimental Periodontitis Induced by Lipopolysaccharide from Porphyromonas gingivalis

• 資料種別: 博士論文
• タイトル: Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Experimental Periodontitis Induced by Lipopolysaccharide from Porphyromonas gingivalis
• 著者・編者: 藤田, 敦子
• 著者標目: 藤田, 敦子
• 並列タイトル等: Porphyromonas gingivalis 由来の LPS を用いた歯周炎モデルラットにおける 11β-HSD1 発現の増加
• 授与機関名: 大阪歯科大学
• 授与年月日: 2018-03-09
• 報告番号: 甲第815号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Chronic Periodontitis; 11β-Hydroxysteroid Dehydrogenase Type 1; Lipopolysaccharide; Porphyromonas gingivalis
• 対象利用者: 一般
• 一般注記: It has been proposed that 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which activates glucocorticoids, plays a role in chronic inflammatory diseases including metabolic diseases, rheumatoid arthritis, and ulcerative colitis. We have recently reported that the expression of 11β-HSD1 is increased in the gingiva of patients with chronic periodontitis and in that of rats with ligature-induced periodontitis. In this study, to further demonstrate the involvement of 11β-HSD1 in chronic periodontitis, the expression of 11β-HSD1 was investigated in another rat model of experimental periodontitis induced by intragingival injection of lipopolysaccharide from Porphyromonas gingivalis (LPS-PG). Alveolar bone loss was observed two weeks after intragingival injection of LPS-PG. The level of 11β-HSD1 mRNA assessed by real-time reverse transcriptase-polymerase chain reaction was significantly elevated in LPS-PG-induced periodontitis compared with controls. The expression of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which inactivates glucocorticoids, was not significantly different between control and LPS-PG-induced periodontitis. The expression of 11β-HSD1 was significantly correlated with that of TNF in LPS-PG-induced periodontitis. The increased expression of 11β-HSD1 protein in LPS-PG-induced periodontitis was confirmed by immunohistochemistry using anti-11β-HSD1 antibody. These results further suggest a role for 11β-HSD1 in the pathogenesis of chronic periodontitis.; 2017年度
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: CC BY-NC-ND
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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