Surface modification of porous alpha-tricalcium phosphate granules with heparin enhanced their early osteogenic capability in a rat calvarial defect model

• 資料種別: 博士論文
• タイトル: Surface modification of porous alpha-tricalcium phosphate granules with heparin enhanced their early osteogenic capability in a rat calvarial defect model
• 著者・編者: 武田, 吉裕
• 著者標目: 武田, 吉裕
• 並列タイトル等: ヘパリンによる表面修飾はα型リン酸三カルシウム多孔質顆粒の初期骨形成能を増強する
• 授与機関名: 大阪歯科大学
• 授与年月日: 2018-03-09
• 報告番号: 甲第818号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: heparin; calcium phosphate; α-tricalcium phosphate; critical size defects; surface modification
• 対象利用者: 一般
• 一般注記: Heparin binds to and modulates various growth factors, potentially augmenting the bone-forming capability of biomaterials. Here, α-tricalcium phosphate (α-TCP) granules were modified with peptide containing the marine mussel-derived adhesive sequence, which reacts with α-TCP surface, and cationic sequence, which binds to heparin (α-Ph).α-Ph retained the α-TCP phase and intergranule spaces after the surface modification. The existence of heparin on α-Ph granules was confirmed using x-ray photoelectron spectroscopy. Granules of α-TCP and α-Ph were implanted into critical-size defects in rat calvaria for 4 weeks. Micro-computed tomography, histological evaluation, and Alcian blue staining revealed that α-Ph induced superior bone formation compared with α-TCP. Newly formed bone on α-Ph was preferentially in contact with the Alcian blue-stained surfaces of granules. These results suggested that heparinization enhanced the early osteogenic capacity of α-TCP, possibly by modulating the secretion of Alcian blue-stained extracellular matrixes.; 2017年度
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: CC BY-NC-ND
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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