並列タイトル等歯肉 iPS 細胞に由来する間葉系幹細胞様細胞からの骨芽細胞様細胞への誘導
一般注記Mesenchymal stem cells (MSCs) have a limited capacity to proliferate in vitro, making it very difficult to acquire sufficient cell numbers for implantation. The objective of this study was to induce MSC-like cells (MSLCs) from human gingival induced pluripotent stem cells (iPSCs) into osteoblast-like cells. We fabricated MSLCs from human gingival iPSCs under the feeder free condition. MSLCs expressing MSC-specific markers treated with osteoblast differentiation factor expressed osteoblast-specific mRNA and protein. Given the higher proliferative capacity of MSLCs, the cells may be a possible source for preparing osteoblast-like cells, applicable for bone regeneration therapy.
2017年度
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース(IRDB)(機関リポジトリ)