Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model

• 資料種別: 博士論文
• タイトル: Functional recovery by application of human dedifferentiated fat cells on cerebral infarction mice model
• 著者・編者: 覺道, 知樹
• 著者標目: 覺道, 知樹
• 並列タイトル等: マウス脳梗塞モデルにおけるヒト脱分化脂肪細胞による機能回復
• 授与機関名: 大阪歯科大学
• 授与年月日: 2018-03-09
• 報告番号: 甲第822号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Adipose stem cell; Cerebral infarction; Cerebrovascular disorder; Nestin; Neural differentiation; Transplantation
• 対象利用者: 一般
• 一般注記: Elderly people whose daily activities have declined due to a cerebrovascular disorder may suffer from dysphagia and may find oral hygiene difficult. Therefore, it is important to establish an effective therapy for the underlying cerebrovascular disorder. Dedifferentiated fat cells (DFAT) were obtained from mature adipocytes isolated from human buccal adipose pads in a ceiling culture. DFAT expressed the neural markers Nestin and SOX2. Flow cytometric analysis revealed that the cells had properties similar to mesenchymal stem cells. Although the transplantation of DFAT did not change the infarction area and volume ratios in a murine cerebral infarction model, functional recovery was observed in behavioral tests. Furthermore, DFAT administered to mice were later detected in cerebral infarctions. It therefore appears that transplanted DFAT affect the brain after infarction and contribute to the promotion of functional recovery. This finding may provide new cell replacement therapy options for treating disorders of the central nervous system.; 2017年度
• 一次資料へのリンクURL: fulltext; https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=184&item_no=1&attribute_id=20&file_no=2; https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=184&item_no=1&attribute_id=20&file_no=1
• オンライン閲覧公開範囲: インターネット公開
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 大阪歯科大学 : 大阪歯科大学学術リポジトリ