Effects of preemptive analgesia with intravenous acetaminophen on postoperative pain relief in patients undergoing third molar surgery: a prospective, single-blind, randomized controlled trial

• 資料種別: 博士論文
• タイトル: Effects of preemptive analgesia with intravenous acetaminophen on postoperative pain relief in patients undergoing third molar surgery: a prospective, single-blind, randomized controlled trial
• 著者・編者: 加納, 慶太
• 著者標目: 加納, 慶太
• 並列タイトル等: アセトアミノフェン静注液の先制投与が智歯抜歯後疼痛に与える影響：前向き単盲検無作為化比較試験
• 授与機関名: 大阪歯科大学
• 授与年月日: 2021-03-05
• 報告番号: 甲第889号
• 学位: 博士（歯学）
• 本文の言語コード: eng
• 件名標目: Preemptive analgesia; acetaminophen; impacted third molar; pain relief; randomized controlled trial
• 対象利用者: 一般
• 一般注記: Background: The efficacy of preemptive analgesia in managing postoperative pain remains controversial. The aim of this study was to compare the efficacy of intravenous (IV) acetaminophen administered before or immediately after the surgical extraction of an impacted mandibular third molar.Material and Methods: This prospective randomized clinical trial included 120 patients. The patients were assigned to one of three groups: the preoperative-treatment group (pre-group), which received 1000 mg of IV acetaminophen 20 min before surgery; the postoperative-treatment group (post-group), which received 1000 mg of IV acetaminophen after surgery; the no-treatment group (control-group), which did not receive any analgesic. Rescue analgesic (60 mg loxoprofen) was issued to each patient, with instructions on self-administration if needed. For the rescue medication usage, the time of first loxoprofen usage and the total amount of loxoprofen consumption were obtained for a 17-hour period after surgery. We measured pain using the visual analogue scale at 1 hour andat 2, 3, 4, 5, and 15 hours after surgery.Results: There was no significant difference in pain level among the three groups at any time interval. However, the pre-group demonstrated significantly lower rescue analgesic consumption and longer time until initial administration.Conclusions: Administration of IV acetaminophen before third molar surgery provides more effective pain control than postoperative administration and no treatment.; 2020年度
• オンライン閲覧公開範囲: インターネット公開
• 著作権情報: CC BY-NC-ND
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 大阪歯科大学 : 大阪歯科大学学術リポジトリ

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https://osaka-dent.repo.nii.ac.jp/?action=repository_action_common_download&item_id=276&item_no=1&attribute_id=20&file_no=2 fulltext

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