Post-ischemic administration of vascular endothelial growth factor inhibitor in a rat model of cerebral venous infarction.

• 資料種別: 博士論文
• タイトル: Post-ischemic administration of vascular endothelial growth factor inhibitor in a rat model of cerebral venous infarction.
• 著者・編者: Miyake, Hitoshi; Nakagawa, Ichiro; Takeshima, Yasuhiro; Nishimura, Fumihiko; Park, Young-Su; Nakamura, Mitsutoshi; Nakase, Hiroyuki
• 著者標目: Miyake, Hitoshi; Nakagawa, Ichiro; Takeshima, Yasuhiro; Nishimura, Fumihiko; Park, Young-Su; Nakamura, Mitsutoshi; Nakase, Hiroyuki
• 出版事項: 日本脳神経外科学会
• 出版年月日等: 2013
• 出版年（W3CDTF）: 2013
• 並列タイトル等: ラット脳静脈モデルにおける血管内皮増殖因子桔抗薬の虚血後投与
• タイトル（掲載誌）: Neurologia medico-chirurgica
• 巻号年月日等（掲載誌）: 53 3
• 掲載巻: 53
• 掲載号: 3
• 掲載ページ: 135-140
• ISSN（掲載誌）: ISSN : 0470-8105
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2013-11-27
• 報告番号: 乙第1321号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: cerebral venous infarction; vascular endothelial growth factor; antagonist; brain edema
• 対象利用者: 一般
• 一般注記: type:Thesis; Cerebral venous ischemia can result in severe brain edema. Inhibition of vascular endothelial growth factor (VEGF) activity by a neutralizing antibody can completely block the hypoxia-induced increase in vascular permeability. VEGF, which induces angiogenesis, also acts as a vascular permeability (VP) factor. We previously showed that inhibition of VEGF attenuates VP and reduces cerebral venous infarction (CVI) in the acute stage. The present study investigated the therapeutic time window during which inhibition of VEGF can reduce CVI in a rat two-vein occlusion (2-VO) model. A 2-VO model was created by photochemically occluding two adjacent cortical veins. Male Wistar rats (n = 42) were assigned to one of four groups: Group 1 was treated with a VEGF antagonist at 24 hours after 2-VO (n = 11); Group 2 was treated with phosphate-buffered solution (PBS) at 24 hours after 2-VO (n = 11); Group 3 was treated with a VEGF antagonist at 48 hours after 2-VO (n = 10); and Group 4 was treated with PBS at 48 hours after 2-VO (n = 10). The developing ischemic infarct was evaluated histologically at 7 days after 2-VO. CVI areas were significantly smaller in Group 1 than in Groups 2, 3, and 4 (p <0.05) but were similar when comparing Groups 3 and 4. Anti-VEGF therapy was effective in reducing CVI in rats if started within 24 hours after 2-VO.; 博士（医学）・乙第1321号・平成25年11月27日; Copyright © 日本脳神経外科学会 | The Japan Neurosurgical Society / 学会誌名（Neurologia medico-chirurgica）とJ-STAGEからの出典である; identifier:Neurologia medico-chirurgica Vol.53 No.3 p.135-140; identifier:04708105; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2676; identifier:Neurologia medico-chirurgica, 53(3): 135-140
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.2176/nmc.53.135
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

目次

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2676/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2676/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2676/6/03%e6%9c%ac%e6%96%87.pdf fulltext