The impact of obstructive sleep apnea syndrome on nocturnal urine production in older men with nocturia.

• 資料種別: 博士論文
• タイトル: The impact of obstructive sleep apnea syndrome on nocturnal urine production in older men with nocturia.
• 著者・編者: Hoshiyama, Fumiaki; Hirayama, Akihide; Tanaka, Masahiro; Taniguchi, Mitsutaka; Ohi, Motoharu; Momose, Hitoshi; Nakamura, Takahito; Ogawa, Shuhei; Torimoto, Kazumasa; Tanaka, Nobumichi; Fujimoto, Kiyohide
• 著者標目: Hoshiyama, Fumiaki; Hirayama, Akihide; Tanaka, Masahiro; Taniguchi, Mitsutaka; Ohi, Motoharu; Momose, Hitoshi; Nakamura, Takahito; Ogawa, Shuhei; Torimoto, Kazumasa; Tanaka, Nobumichi; Fujimoto, Kiyohide
• 出版事項: Elsevier Science
• 出版年月日等: 2014-10
• 出版年（W3CDTF）: 2014-10
• 並列タイトル等: 高齢夜間頻尿患者における夜間尿産生に対する閉塞性睡眠時無呼吸症候群の影響
• タイトル（掲載誌）: Urology
• 巻号年月日等（掲載誌）: 84 4
• 掲載巻: 84
• 掲載号: 4
• 掲載ページ: 892-896
• ISSN（掲載誌）: ISSN : 0090-4295
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2014-12-03
• 報告番号: 乙第1349号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 対象利用者: 一般
• 一般注記: type:Thesis; OBJECTIVE: To investigate the impact of obstructive sleep apnea syndrome (OSAS) on night-time secretion of brain natriuretic peptide (BNP) and antidiuretic hormone (ADH) in older men with nocturia accompanied by nocturnal polyuria. MATERIALS AND METHODS: One hundred six men with nocturia aged ≥ 60 years underwent full-night polysomnography to determine whether they had OSAS. Blood count, standard chemistry panel, BNP, urinary ADH, urinary creatinine (u-Cre), and urinary osmolarity were measured at 6:00 AM, and a frequency volume chart was recorded on the same day that polysomnography was performed. RESULTS: We evaluated 83 patients after excluding 18 with mild OSAS and 5 with nocturnal polyuria index <0.35. Participants with OSAS had higher apnea-hypopnea index (P < .0001) than those without OSAS. Body mass index and systolic blood pressure were higher in OSAS patients than those in the control group. BNP was higher in the OSAS patients than in the control patients (48.6 ± 41.4 vs 30.7 ± 31.5; P = .0006). On urinalysis, OSAS patients showed higher urinary sodium and u-Cre secretion than controls (24.7 ± 11.3 vs 16.2 ± 5.1; P <.0001). Urine osmolarity was also higher in OSAS patients than in the control patients (616 ± 172 vs 516 ± 174; P = .0285). There was no significant difference in urinary ADH and u-Cre (6.7 ± 10.4 vs 6.8 ± 7.8; P = .3617) between the 2 groups. CONCLUSION: Our results indicated that older men with nocturnal polyuria and OSAS did not compensate their fluid imbalance presented with decreased secretion of ADH but increased BNP level.; 博士（医学）・乙第1349号・平成26年12月3日; Copyright © 2014 Elsevier Inc. All rights reserved.; identifier:Urology Vol.84 No.4 p.892-896; identifier:00904295; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2753; identifier:Urology, 84(4): 892-896
• 一次資料へのリンクURL: fulltext; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2753/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2753/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf; http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2753/6/03%e6%9c%ac%e6%96%87.pdf
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1016/j.urology.2014.02.073
• 掲載誌（NCID）: AA0087924X; https://ci.nii.ac.jp/ncid/AA0087924X
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU