Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris.

• 資料種別: 博士論文
• タイトル: Histological and molecular characterization of the femoral attachment of the human ligamentum capitis femoris.
• 著者・編者: Shinohara, Yasushi; Kumai, Tsukasa; Higashiyama, Ichiro; Hayashi, Koji; Matsuda, Takenori; Tanaka, Yasuhito; Takakura, Yoshinoi
• 著者標目: Shinohara, Yasushi; Kumai, Tsukasa; Higashiyama, Ichiro; Hayashi, Koji; Matsuda, Takenori; Tanaka, Yasuhito; Takakura, Yoshinoi
• 出版事項: Wiley
• 出版年月日等: 2014-08
• 出版年（W3CDTF）: 2014-08
• 並列タイトル等: 大腿骨頭靭帯の組織学的および分子学的特性に関する研究
• タイトル（掲載誌）: Scandinavian journal of medicine & science in sports
• 巻号年月日等（掲載誌）: 24 4
• 掲載巻: 24
• 掲載号: 4
• 掲載ページ: e245-e253
• ISSN（掲載誌）: ISSN : 0905-7188
• 授与機関名: 奈良県立医科大学
• 授与年月日: 2015-03-16
• 報告番号: 乙第1353号
• 学位: 博士（医学）
• 本文の言語コード: eng
• 件名標目: enthesis; stability; stress deprivation; ligament rupture
• 対象利用者: 一般
• 一般注記: type:Thesis; The ligamentum capitis femoris (LCF) has increased in clinical significance through the development of hip arthroscopy. The histological pathologies and molecular composition of the femoral attachment of the LCF and the degeneration caused by LCF disruption were investigated in the human hip joint. Twenty-four LCFs were retrieved at surgery for femoral neck fracture (age range: 63–87 years). In the “intact” (i.e., intact throughout its length, n = 12) group, the attachment consisted of rich fibrocartilage. Fibrocartilage cells were present in the midsubstance. In contrast, the construction of the attachment in the “disrupted” (i.e., ligament no longer attached to the femoral head, n = 12) group had disappeared. The attachment in the disrupted group was not labeled for type II collagen or aggrecan, while that in the intact group was labeled for types I, II and III collagen, chondroitin 4-sulfate, chondroitin 6-sulfate, aggrecan, and versican. The percentage of single-stranded DNA-positive chondrocytes was significantly higher in the disrupted group than in the intact group. We conclude that the femoral attachment of the LCF has a characteristic fibrocartilaginous structure that is likely to adjust to the mechanical load, and suggest that its degeneration is advanced by disruption and should be regarded as a clinical pathology.; 博士（医学）・乙第1353号・平成27年3月16日; © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.; identifier:Scandinavian journal of medicine & science in sports Vol.24 No.4, p.e245-e253; identifier:09057188; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2970; identifier:Scandinavian journal of medicine & science in sports, 24(4): e245-e253
• オンライン閲覧公開範囲: インターネット公開
• 関連情報（DOI）: 10.1111/sms.12155
• 連携機関・データベース: 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• 提供元機関・データベース: 奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU

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http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2970/1/01%e6%9c%ac%e6%96%87%e3%81%ae%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2970/2/02%e5%af%a9%e6%9f%bb%e8%a6%81%e6%97%a8.pdf fulltext

http://ginmu.naramed-u.ac.jp/dspace/bitstream/10564/2970/6/03%e6%9c%ac%e6%96%87.pdf fulltext