並列タイトル等大腿骨頭靭帯の組織学的および分子学的特性に関する研究
タイトル（掲載誌）Scandinavian journal of medicine & science in sports
一般注記type:Thesis
The ligamentum capitis femoris (LCF) has increased in clinical significance through the development of hip arthroscopy. The histological pathologies and molecular composition of the femoral attachment of the LCF and the degeneration caused by LCF disruption were investigated in the human hip joint. Twenty-four LCFs were retrieved at surgery for femoral neck fracture (age range: 63–87 years). In the “intact” (i.e., intact throughout its length, n = 12) group, the attachment consisted of rich fibrocartilage. Fibrocartilage cells were present in the midsubstance. In contrast, the construction of the attachment in the “disrupted” (i.e., ligament no longer attached to the femoral head, n = 12) group had disappeared. The attachment in the disrupted group was not labeled for type II collagen or aggrecan, while that in the intact group was labeled for types I, II and III collagen, chondroitin 4-sulfate, chondroitin 6-sulfate, aggrecan, and versican. The percentage of single-stranded DNA-positive chondrocytes was significantly higher in the disrupted group than in the intact group. We conclude that the femoral attachment of the LCF has a characteristic fibrocartilaginous structure that is likely to adjust to the mechanical load, and suggest that its degeneration is advanced by disruption and should be regarded as a clinical pathology.
博士（医学）・乙第1353号・平成27年3月16日
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
identifier:Scandinavian journal of medicine & science in sports Vol.24 No.4, p.e245-e253
identifier:09057188
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/2970
identifier:Scandinavian journal of medicine & science in sports, 24(4): e245-e253
連携機関・データベース国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
提供元機関・データベース奈良県立医科大学 : 奈良県立医科大学機関リポジトリ GINMU